About: The Etiologic, Microbiologic, Clinical and Outcome Characteristics of Immunocompetent Young Children < 2 Years of Age Hospitalized with Acute Neutropenia

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Etiologic, Microbiologic, Clinical and Outcome Characteristics of Immunocompetent Young Children < 2 Years of Age Hospitalized with Acute Neutropenia
Creator	Fruchtman, Yariv Sergienko, Ruslan David, Ron Dov, Tschernin Leibovitz, Leibovitz, Julia Ma, Odeya Mazar, Eugene
source	Elsevier; Medline; PMC
abstract	Abstract Objectives To describe the etiologic, microbiologic, clinical and outcome characteristics of acute neutropenia (absolute neutrophil count, ANC, <1.5 × 109/L) in hospitalized immunocompetent children. Methods Serious bacterial infections (SBI) were defined as culture-positive blood, urine, cerebrospinal fluid, articular fluid or stool infections, alveolar pneumonia, Brucellosis and Rickettsiosis. Results 431/671 (64.2%) healthy infants and children hospitalized with acute neutropenia were <2 years of age; 176 (40.8%), 167 (38.8%) and 88 (20.4%) patients were aged 0–3, 4–12 and 13–24 months, respectively. There were 19 (4.4%), 53 (12.3%), 140 (32.5%) and 209 (50.8%) patients with ANC count <200, 200–500, 501–1000 and 1001–1500 × 109 cells/L, respectively. Severe neutropenia (<500 ×109/L) was recorded in 72 (16.7%) patients. Fever >380C was present in 208/431 (48.3%) patients. Blood cultures were positive in 10 (2.3%), with Brucella melitensis, Staphylococcus aureus and Enterobacter spp. identified in 4, 3 and 2 patients, respectively; 5/10 patients with positive blood cultures were < 3 months of age. Overall, 55/431 (12.7%) and 65/431 (15.1%) patients were diagnosed with SBIs and bacterial infections, respectively. Nasal washings-PCR for respiratory viruses was positive in 139/293 (47.4%) patients tested. An infectious etiology (bacterial and/or viral) was diagnosed in 190/431 (44.1%) patients. Three patients were diagnosed with acute lymphocytic leukemia. Resolution of neutropenia was achieved in 111/208 (53.4%) evaluable patients (63%, 50.6% and 48% of patients aged 0–3, 4–12 and >12 months, respectively and 56.8%, 53.5% and 52% of patients with severe, moderate and mild neutropenia, respectively). Conclusions Acute neutropenia is common in immunocompetent children < 2 years of age and is frequently associated with viral infections. We showed a substantial involvement of bacterial infections and particularly SBIs in the etiology of acute neutropenia. After a 1-month follow-up, resolution of neutropenia occurred in half of the patients, without association with age subgroups and with neutropenia severity.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.1016/j.pedneo.2020.08.004
bibo:pmid	32847741
has license	els-covid
sha1sum (hex)	deba9d017ec0144fa3294dd5cf91beb8e354fd0f
schema:url	https://doi.org/10.1016/j.pedneo.2020.08.004
resource representing a document's title	The Etiologic, Microbiologic, Clinical and Outcome Characteristics of Immunocompetent Young Children < 2 Years of Age Hospitalized with Acute Neutropenia
has PubMed Central identifier	PMC7419265
has PubMed identifier	32847741
schema:publication	Pediatr Neonatol
resource representing a document's body	covid:deba9d017ec0144fa3294dd5cf91beb8e354fd0f#body_text
is schema:about of	named entity 'Acute' named entity 'Children' named entity 'follow-up' named entity 'Neutropenia' named entity 'pneumonia' named entity 'etiology' named entity 'emergency room' named entity 'ANC' named entity 'WBC' named entity 'immunocompetent' named entity 'immunocompetent' named entity 'etiology' named entity 'neutropenia' named entity 'bone marrow examination' named entity 'Thrombocytopenia' named entity 'neutropenia' named entity 'work-up' named entity 'neutropenia' named entity 'viral pathogens' named entity 'acute lymphocytic leukemia' named entity 'neutropenia' named entity 'neutropenia' named entity 'bacterial gastroenteritis' named entity 'leukopenic' named entity 'follow-up' named entity 'intravenous' named entity 'congenital' named entity 'WBC' named entity 'sepsis' named entity 'etiology' named entity 'Brucellosis' named entity 'ANC' named entity 'ceftriaxone' named entity 'standard deviations' named entity 'platelet count' named entity 'bacterial infections' named entity 'immunocompetent' named entity 'neutropenia' named entity 'follow-up' named entity 'H. influenzae' named entity 'hemoglobin' named entity 'acute otitis media' named entity 'nasopharyngeal' named entity 'young children' named entity 'leukemia' named entity 'ampicillin' named entity 'Israel' named entity 'Leukopenia' named entity 'septic arthritis' named entity 'pneumonia' named entity 'empiric treatment' named entity 'blood cultures' named entity 'etiology' named entity 'thrombocytopenia' named entity 'alveolar' named entity 'neutropenia' named entity 'urinary tract infection' named entity 'Rickettsiosis' named entity 'neutropenia' named entity 'differential diagnosis' named entity 'Anemia' named entity 'bacterial meningitis' named entity 'epidemiologic' named entity 'vomiting' named entity 'upper respiratory infection' named entity 'infection' named entity 'febrile' named entity 'acute otitis media' named entity 'young children' named entity 'osteomyelitis' named entity 'neutropenia' named entity 'anemia' named entity 'gentamicin' named entity 'viruses'

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