About: Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma
Creator	Aiyar, Ashok Nagamatsu, Takeshi Fontanilla, Francis Ibana, Joyce Quayle, Alison Schust, Danny Sherchand, Shardulendra
Source	Medline; PMC
abstract	The intracellular bacterial pathogen, Chlamydia trachomatis, is a tryptophan auxotroph. Therefore, induction of the host tryptophan catabolizing enzyme, indoleamine-2,3-dioxgenase-1 (IDO1), by interferon gamma (IFNγ) is one of the primary protective responses against chlamydial infection. However, despite the presence of a robust IFNγ response, active and replicating C. trachomatis can be detected in cervical secretions of women. We hypothesized that a primary C. trachomatis infection may evade the IFNγ response, and that the protective effect of this cytokine results from its activation of tryptophan catabolism in bystander cells. To test this hypothesis, we developed a novel method to separate a pool of cells exposed to C. trachomatis into pure populations of live infected and bystander cells and applied this technique to distinguish between the effects of IFNγ on infected and bystander cells. Our findings revealed that the protective induction of IDO1 is suppressed specifically within primary infected cells because Chlamydia attenuates the nuclear import of activated STAT1 following IFNγ exposure, without affecting STAT1 levels or phosphorylation. Critically, the IFNγ-mediated induction of IDO1 activity is unhindered in bystander cells. Therefore, the IDO1-mediated tryptophan catabolism is functional in these cells, transforming these bystander cells into inhospitable hosts for a secondary C. trachomatis infection.
has issue date	2018-05-31(xsd:dateTime)
bibo:doi	10.1038/s41598-018-26765-y
bibo:pmid	29855501
has license	cc-by
sha1sum (hex)	e1684d4ad73d5982451ae73e97542c2559c04038
schema:url	https://doi.org/10.1038/s41598-018-26765-y
resource representing a document's title	Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma
has PubMed Central identifier	PMC5981614
has PubMed identifier	29855501
schema:publication	Sci Rep
resource representing a document's body	covid:e1684d4ad73d5982451ae73e97542c2559c04038#body_text
is schema:about of	named entity 'OPEN' named entity 'activity' named entity 'host' named entity 'tryptophan' named entity 'IDO1' named entity 'cytokine' named entity 'responses' named entity 'OPEN' named entity 'INTERFERON GAMMA ' named entity 'RESPONSES' named entity 'REPLICATING' named entity 'ACTIVE' named entity 'SECONDARY' named entity 'CHLAMYDIA TRACHOMATIS' named entity 'INTERFERON GAMMA ' named entity 'PRESENCE OF' named entity 'CHLAMYDIA' named entity 'FINDINGS' named entity 'NOVEL' named entity 'TRYPTOPHAN CATABOLISM' named entity 'IDO1' named entity 'ROBUST' named entity 'WOMEN' named entity 'RESPONSE' named entity 'CERVICAL SECRETIONS' named entity 'REVEALED' named entity 'PHOSPHORYLATION' named entity 'METHOD' named entity 'POOL' named entity 'PROTECTIVE EFFECT' named entity 'OUR' named entity 'INFECTED' named entity 'EXPOSURE' named entity 'TO SEPARATE' named entity 'TECHNIQUE' named entity 'EXPOSED TO' named entity 'FOLLOWING' named entity 'LIVE' named entity 'CYTOKINE ' named entity 'BYSTANDER' named entity 'LEVELS' named entity 'TO TEST' named entity 'TRANSFORMING' named entity 'INTRACELLULAR' named entity 'NUCLEAR IMPORT' named entity 'THESE' named entity 'CELLS' named entity 'CHLAMYDIA TRACHOMATIS' named entity 'PURE' named entity 'CELLS' named entity 'ACTIVATION' named entity 'UNINFECTED' named entity 'INFECTED' named entity 'EXHIBIT' named entity 'BYSTANDER' named entity 'HOST' named entity 'MEDIATED' named entity 'HYPOTHESIS' named entity 'BACTERIAL PATHOGEN' named entity 'INDOLEAMINE' named entity 'SUPPRESSED' named entity 'DETECTED' named entity 'STAT1' named entity 'ITS' named entity 'INDUCTION' named entity 'EFFECTS' named entity 'IS A' named entity 'IFN' named entity 'PRIMARY' named entity 'INFECTION' named entity 'ACTIVITY' named entity 'ONE OF' named entity 'CHLAMYDIAL INFECTION' named entity 'AFFECTING' named entity 'RESULTS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software