About: Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration

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About: Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration
Creator	Wang, Yan Xue, Yun Jia, Meng-Qi Xiong, Ye-Juan Yan, Chao
source	Medline; PMC
abstract	Yupingfeng (YPF), a famous traditional Chinese medicine, which contains a large array of compounds, has been effectually used in health protection. A two-dimensional liquid chromatography ((2)D-LC) combined with quadrupole time-of-flight mass spectrometry (QTOF-MS) method was firstly established to separate and identify chemical components in YPF. A total of 33 compounds were identified, including 15 constituents (flavonoids and saponins) in Astragali radix; seven constituents (sesquiterpenoids and polysaccharide) in Atractylodis rhizoma; and 11 constituents (chromone and coumarins) in Saposhnikoviae radix. The corresponding fragmentation pathway of typical substances was investigated. Then, seven active constituents (astragaloside, calycosin, formononetin, cimicifugoside, 4-O-beta-d-glucosyl-5-O-methylvisamminol, sec-O-glucosylhamaudol, and atractylenolide II) derived from three medicinal plants were chosen to further investigate the pharmacokinetic behavior of YPF formula using ultrahigh-performance liquid chromatography with triple quadrupole mass spectrometry system. The method was sensitive, accurate and reliable. We also used the area under the plasma concentration–time curve from zero to infinity (AUC(0−∞)) as weighting factor to make an integrated pharmacokinetic curve. Results show that the constituents of Saposhnikoviae radix have the best absorption and pharmacokinetic behavior and may play important role in leading to the changes of overall therapeutic effects of YPF. Further study is needed to confirm the association between them.
has issue date	2017-05-17(xsd:dateTime)
bibo:doi	10.3390/molecules22050810
bibo:pmid	28513568
has license	cc-by
sha1sum (hex)	e1c5d3a82f4296f2867ccca63989530f17a773d7
schema:url	https://doi.org/10.3390/molecules22050810
resource representing a document's title	Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration
has PubMed Central identifier	PMC6154636
has PubMed identifier	28513568
schema:publication	Molecules
resource representing a document's body	covid:e1c5d3a82f4296f2867ccca63989530f17a773d7#body_text
is schema:about of	named entity 'INTEGRATED' named entity 'RADIX' named entity 'SEC-O-GLUCOSYLHAMAUDOL' named entity 'STUDY' named entity 'CHOSEN' named entity 'TRIPLE' named entity 'TRADITIONAL CHINESE MEDICINE' named entity 'ROLE' named entity 'TO SEPARATE' named entity 'TYPICAL' named entity 'HEALTH' named entity 'AREA' named entity 'ESTABLISHED' named entity 'EFFECTS' named entity 'RELIABLE' named entity 'PLASMA CONCENTRATION' named entity 'INCLUDING' named entity '5-O-METHYLVISAMMINOL' named entity 'ACCURATE' named entity 'BETA-D-GLUCOSYL' named entity 'COMPONENTS' named entity 'THERAPEUTIC' named entity 'INVESTIGATED' named entity 'SAPOSHNIKOVIAE RADIX' named entity 'COUMARINS' named entity 'MEDICINAL PLANTS' named entity 'YUPINGFENG' named entity 'PHARMACOKINETIC STUDY' named entity 'USING' named entity 'INFINITY' named entity 'LEADING' named entity 'ASTRAGALI' named entity 'ARRAY' named entity 'ATRACTYLENOLIDE II' named entity 'CONTAINS' named entity 'FRAGMENTATION' named entity 'USING' named entity 'CONSTITUENTS' named entity 'FORMULA' named entity 'PHARMACOKINETIC' named entity 'ATRACTYLODIS RHIZOMA' named entity 'QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY' named entity 'CHANGES' named entity 'ASSOCIATION' named entity 'FORMONONETIN' named entity 'INVESTIGATE' named entity 'METHOD' named entity 'ZERO' named entity 'IDENTIFY' named entity 'CALYCOSIN' named entity 'DERIVED' named entity 'COMBINED' named entity 'CHEMICAL' named entity 'IDENTIFIED' named entity 'EXTRACTS' named entity 'PLASMA' named entity 'RAT' covid:arg/e1c5d3a82f4296f2867ccca63989530f17a773d7 named entity 'ORAL ADMINISTRATION' named entity 'MOLECULES' named entity 'APPLICATION' named entity 'COMPONENTS' named entity 'ACTIVE' named entity 'CHARACTERIZATION' named entity 'UPLC-MS' named entity 'USED' named entity 'YUPINGFENG' named entity 'CONFIRM' named entity 'HAVE' named entity 'TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY' named entity 'POLYSACCHARIDE' named entity 'MAKE' named entity 'ACTIVE' named entity 'PATHWAY' named entity 'SEVEN' named entity 'BEST' named entity 'LIQUID CHROMATOGRAPHY '

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