About: A health concern regarding the protein corona, aggregation and disaggregation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A health concern regarding the protein corona, aggregation and disaggregation
Creator	Attar, Farnoosh Berret, Jean-François Falahati, Mojtaba Haertlé, Thomas Sharifi, Majid Hasan Khan, Rizwan Saboury, Ali
source	ArXiv; Elsevier; Medline; PMC
abstract	Abstract Nanoparticle (NP)–protein complexes exhibit the “correct identity” of NP in biological media. Therefore, protein–NP interactions should be closely explored to understand and modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, morphology of NPs, and influence of pH on the formation of protein corona and conformational changes of adsorbed proteins by different kinds of techniques. Also, the impact of protein corona on the colloidal stability of NPs is discussed. Uncontrolled protein attachment on NPs may bring unwanted impacts such as protein denaturation and aggregation. In contrast, controlled protein adsorption by optimal concentration, size, pH, and surface modification of NPs may result in potential implementation of NPs as therapeutic agents especially for disaggregation of amyloid fibrils. Also, the effect of NPs-protein corona on reducing the cytotoxicity and clinical implications such as drug delivery, cancer therapy, imaging and diagnosis will be discussed. Validated correlative physicochemical parameters for NP–protein corona formation frequently derived from protein corona fingerprints of NPs which are more valid than the parameters obtained only on the base of NP features. This review may provide useful information regarding the potency as well as the adverse effects of NPs to predict their behavior in vivo.
has issue date	2019-05-31(xsd:dateTime)
bibo:doi	10.1016/j.bbagen.2019.02.012
bibo:pmid	30802594
has license	els-covid
sha1sum (hex)	e22e7a013f55a9947a5044ac0fec135ccb1ce917
schema:url	https://doi.org/10.1016/j.bbagen.2019.02.012
resource representing a document's title	A health concern regarding the protein corona, aggregation and disaggregation
has PubMed Central identifier	PMC7115795
has PubMed identifier	30802594
schema:publication	Biochimica et Biophysica Acta (BBA) - General Subjects
resource representing a document's body	covid:e22e7a013f55a9947a5044ac0fec135ccb1ce917#body_text
is schema:about of	named entity 'Uncontrolled' named entity 'proteins' named entity 'stability' named entity 'fingerprints' named entity 'protein denaturation' named entity 'reducing' named entity 'disaggregation' named entity 'protein' named entity 'modulate' named entity 'medium' named entity 'result' named entity 'corona' named entity 'NPs' named entity 'impact' named entity 'nature' named entity 'NPs' named entity 'potency' named entity 'kinds' named entity 'adverse effects' named entity 'corona' named entity 'Therefore' named entity 'drug delivery' named entity 'NPs' named entity 'NPs' named entity 'colloidal' named entity 'protein' named entity 'concentration' named entity 'serum concentrations' named entity 'physicochemical' named entity 'nanomaterials' named entity 'immunoglobulin' named entity 'protein secondary structure' named entity 'NPs' named entity 'copolymer' named entity 'ROS' named entity 'cytotoxicity' named entity 'NPs' named entity 'conformation' named entity 'nanomaterials' named entity 'protein' named entity 'protein' named entity 'vaccines' named entity 'Phe' named entity 'protein' named entity 'nucleation' named entity 'albumin' named entity 'cytotoxicity' named entity 'NPs' named entity 'NPs' named entity 'NPs' named entity 'anti-tumor' named entity 'cellular uptake' named entity 'polysaccharides' named entity 'NPs' named entity 'biological role' named entity 'biomolecules' named entity 'NPs' named entity 'protein' named entity 'protein' named entity 'metal oxide' named entity 'protein' named entity 'QSAR' named entity 'mice' named entity 'zeta potential' named entity 'NPs' named entity 'nanoparticle' named entity 'NPs' named entity 'incubation' named entity 'NPs' named entity 'physiological pH' named entity 'adsorption' named entity 'NPs' named entity 'carcinoma' named entity 'infection' named entity 'biophysical approaches'

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