About: Viral diversity in swine intestinal mucus used for the manufacture of heparin as analyzed by high-throughput sequencing

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About: Viral diversity in swine intestinal mucus used for the manufacture of heparin as analyzed by high-throughput sequencing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral diversity in swine intestinal mucus used for the manufacture of heparin as analyzed by high-throughput sequencing
Creator	Eloit, Marc Cheval, Justine Muth, Erika Dumarest, Marine Ebert B , L Ea Gagnieur, Charles Ene Gratigny, Marl
Source	Elsevier; Medline; PMC
abstract	Abstract Heparin is one of the main pharmaceutical products manufactured from raw animal material. In order to describe the viral burden associated with this raw material, we performed high-throughput sequencing (HTS) on mucus samples destined for heparin manufacturing, which were collected from European pigs. We identified Circoviridae and Parvoviridae members as the most prevalent contaminating viruses, together with viruses from the Picornaviridae, Astroviridae, Reoviridae, Caliciviridae, Adenoviridae, Birnaviridae, and Anelloviridae families. Putative new viral species were also identified. The load of several known or novel small non-enveloped viruses, which are particularly difficult to inactivate or eliminate during heparin processing, was quantified by qPCR. Analysis of the combined HTS and specific qPCR results will influence the refining and validation of inactivation procedures, as well as aiding in risk analysis of viral heparin contamination.
has issue date	2015-01-31(xsd:dateTime)
bibo:doi	10.1016/j.biologicals.2014.10.004
bibo:pmid	25466699
has license	els-covid
sha1sum (hex)	e23f72c9a9d9f32e96b5cfadc1f7f4c06498caa4
schema:url	https://doi.org/10.1016/j.biologicals.2014.10.004
resource representing a document's title	Viral diversity in swine intestinal mucus used for the manufacture of heparin as analyzed by high-throughput sequencing
has PubMed Central identifier	PMC7172073
has PubMed identifier	25466699
schema:publication	Biologicals
resource representing a document's body	covid:e23f72c9a9d9f32e96b5cfadc1f7f4c06498caa4#body_text
is schema:about of	named entity 'raw material' named entity 'members' named entity 'destined' named entity 'processing' named entity 'INFLUENCE' named entity 'HTS' named entity 'LOAD' named entity 'PERFORMED' named entity 'TO DESCRIBE' named entity 'CALICIVIRIDAE' named entity 'MEMBERS' named entity 'DIFFICULT' named entity 'COMBINED' named entity 'ANIMAL MATERIAL' named entity 'PHARMACEUTICAL' named entity 'KNOWN' named entity 'PIGS' named entity 'EUROPEAN' named entity 'Anelloviridae' named entity 'viruses' named entity 'procedures' named entity 'HTS' named entity 'Picornaviridae' named entity 'Parvoviridae' named entity 'qPCR' named entity 'influence' named entity 'material' named entity 'Astroviridae' named entity 'enveloped viruses' named entity 'Birnaviridae' named entity 'Parvoviridae' named entity 'HTS' named entity 'heparin' named entity 'viral species' named entity 'heparin' named entity 'mucus' named entity 'heparin' named entity 'coronaviruses' named entity 'viruses' named entity 'infectious bursal disease' named entity '19, 20' named entity 'viral burden' named entity 'heparin' named entity 'North America' named entity 'pig' named entity 'heparin' named entity 'assay' named entity 'Europe' named entity 'viruses' named entity '9/10' named entity 'vertebrate viruses' named entity 'virus' named entity 'polymerase' named entity 'viruses' named entity 'viral species' named entity 'nanofiltration' named entity 'intestinal mucosa' named entity 'porcine' named entity 'high molecular weight' named entity 'viruses' named entity 'viral burden' named entity 'viruses' named entity 'pig' named entity 'ultracentrifugation' named entity 'supernatants' named entity 'Parvoviridae' named entity 'porcine' named entity 'nucleic acids' named entity 'porcine' named entity 'diarrhea' named entity 'viruses' named entity 'Merck Millipore' named entity 'Reoviridae' named entity 'raw material' named entity 'viral genomes' named entity 'BlastN'

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