About: Chimeric calicivirus-like particles elicit specific immune responses in pigs

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chimeric calicivirus-like particles elicit specific immune responses in pigs
Creator	Baratelli, M Blanco, E Bárcena, J Cabezón, R Costa, C Crisci, E Fraile, L Ganges, L Martinez-Orellana, P Martínez, J Montoya, M Moreno, N Mussá, T
Source	Elsevier; Medline; PMC
abstract	Abstract Virus-like particles (VLPs) have received considerable attention due to their potential application in veterinary vaccines and, in particular, VLPs from rabbit haemorrhagic disease virus (RHDV) have successfully shown to be good platforms for inducing immune responses against an inserted foreign epitope in mice. The aim of this study was to assess the immunogenicity of chimeric RHDV-VLPs as vaccine vectors in pigs. For this purpose, we have generated chimeric VLPs containing a well-known T epitope of 3A protein of foot-and-mouth disease virus (FMDV). Firstly, RHDV-VLPs were able to activate immature porcine bone marrow-derived dendritic cells (poBMDCs) in vitro. Secondly, pigs were inoculated twice in a two-week interval with chimeric RHDV-VLPs at different doses intranasally or intramuscularly. One intramuscularly treated group was also inoculated with adjuvant Montanide™ ISA 206 at the same time. Specific IgG and IgA antibodies against RHDV-VLPs were induced and such levels were higher in the adjuvanted group compared with other groups. Interestingly, anti-RHDV-VLP IgA responses were higher in groups inoculated intramuscularly than those that received the VLPs intranasally. Two weeks after the last immunisation, specific IFN-γ-secreting cells against 3A epitope and against RHDV-VLPs were detected in PBMCs by ELISPOT. The adjuvanted group exhibited the highest IFN-γ-secreting cell numbers and lymphoproliferative specific T cell responses against 3A epitope and RHDV-VLP. This is the first immunological report on the potential use of chimeric RHDV-VLPs as antigen carriers in pigs.
has issue date	2012-03-23(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2012.01.069
bibo:pmid	22306796
has license	els-covid
sha1sum (hex)	e532698cbb198415437014fb1427e4016b3d5e77
schema:url	https://doi.org/10.1016/j.vaccine.2012.01.069
resource representing a document's title	Chimeric calicivirus-like particles elicit specific immune responses in pigs
has PubMed Central identifier	PMC7115503
has PubMed identifier	22306796
schema:publication	Vaccine
resource representing a document's body	covid:e532698cbb198415437014fb1427e4016b3d5e77#body_text
is schema:about of	named entity 'epitope' named entity 'time' named entity 'This' named entity 'group' named entity 'immunisation' named entity 'chimeric' named entity 'For' named entity 'adjuvant' named entity 'vectors' named entity 'inoculated' named entity 'application' named entity 'veterinary' named entity 'immune responses' named entity 'ABLE TO' named entity 'LIKE' named entity 'INSERTED' named entity 'DETECTED' named entity 'HAVE' named entity 'GOOD' named entity 'VLP' named entity 'EPITOPE' named entity 'IFN' covid:arg/e532698cbb198415437014fb1427e4016b3d5e77 named entity 'VACCINES' named entity 'PARTICULAR' named entity 'CHIMERIC' named entity 'TIME' named entity 'ELISPOT' named entity 'BONE MARROW' named entity 'ACTIVATE' named entity 'VETERINARY' named entity 'POTENTIAL' named entity 'FIRSTLY' named entity 'ADJUVANT' named entity 'CONSIDERABLE' named entity 'PARTICLES' named entity 'IMMUNE RESPONSES' named entity 'MICE' named entity 'TWICE' named entity 'CELLS' named entity 'SPECIFIC' named entity 'VIRUS-LIKE PARTICLES' named entity 'CHIMERIC' named entity 'ELICIT' named entity 'CONTAINING' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'VACCINE' named entity 'TREATED' named entity 'RECEIVED' named entity 'LEVELS' named entity 'IN VITRO' named entity 'CELL' named entity 'IGA' named entity 'PIGS' named entity 'SPECIFIC' named entity 'PIGS' named entity 'VECTORS' named entity 'WEEK' named entity 'IMMUNE RESPONSES' named entity 'HIGHEST' named entity 'HIGHER' named entity 'SECRETING' named entity 'T CELL' named entity 'ANTIGEN' named entity 'NUMBERS' named entity 'DUE TO' named entity 'CARRIERS' named entity 'TWO WEEKS' named entity 'REPORT'

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