About: Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core

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About: Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core
Creator	Gao, Feng Ma, Guangpeng Li, Yijing Feng, Youjun Liu, Cheng Wang, Jinzi
Source	Elsevier; Medline; PMC
abstract	Abstract Transmissible gastroenteritis coronavirus (TGEV) is one of the most destructive agents, responsible for the enteric infections that are lethal for suckling piglets, causing enormous economic loss to the porcine fostering industry every year. Although it has been known that TGEV spiker protein is essential for the viral entry for many years, the detail knowledge of the TGEV fusion protein core is still very limited. Here, we report that TGEV fusion core (HR1-SGGRGG-HR2), in vitro expressed in GST prokaryotic expression system, shares the typical properties of the trimer of coiled-coil heterodimer (six α-helix bundle), which has been confirmed by a combined series of biochemical and biophysical evidences including size exclusion chromatography (gel-filtration), chemical crossing, and circular diagram. The 3D homologous structure model presents its most likely structure, extremely similar to those of the coronaviruses documented. Taken together, TGEV spiker protein belongs to the class I fusion protein, characterized by the existence of two heptad-repeat (HR) regions, HR1 and HR2, and the present knowledge about the truncated TGEV fusion protein core may facilitate in the design of the small molecule or polypeptide drugs targeting the membrane fusion between TGEV and its host.
has issue date	2005-12-02(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.09.189
bibo:pmid	16236266
has license	els-covid
sha1sum (hex)	e54a7e2b13048a2c79e39de20d940aaab85136ad
schema:url	https://doi.org/10.1016/j.bbrc.2005.09.189
resource representing a document's title	Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core
has PubMed Central identifier	PMC7092864
has PubMed identifier	16236266
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:e54a7e2b13048a2c79e39de20d940aaab85136ad#body_text
is schema:about of	named entity 'CORE' named entity 'chemical' named entity 'protein' named entity 'viral entry' named entity 'biophysical' named entity 'belongs' named entity 'PORCINE' named entity 'CONFIRMED BY' named entity 'CHARACTERIZED' named entity 'IN VITRO' named entity 'DIAGRAM' named entity 'A-HELIX' named entity 'MEMBRANE FUSION' named entity 'FUSION PROTEIN' named entity 'EXPRESSION SYSTEM' named entity 'ESSENTIAL' named entity 'INFECTIONS' named entity 'SIZE EXCLUSION CHROMATOGRAPHY' named entity 'CIRCULAR' named entity 'REGIONS' named entity 'INDUSTRY' named entity 'EXTREMELY' named entity 'INCLUDING' named entity 'BIOPHYSICAL' covid:arg/e54a7e2b13048a2c79e39de20d940aaab85136ad named entity 'VERY LIMITED' named entity 'HOMOLOGOUS' named entity 'TRUNCATED' named entity 'LETHAL' named entity 'PRESENT' named entity 'STRUCTURE MODEL' named entity 'CLASS I' named entity 'REPORT' named entity 'SERIES' named entity 'ENTERIC' named entity 'PROPERTIES' named entity 'BIOCHEMICAL' named entity 'CHARACTERIZATION' named entity 'ABOUT' named entity 'HR1' named entity 'FOSTERING' named entity 'SMALL MOLECULE' named entity 'PROTEIN ' named entity 'KNOWN' named entity 'KNOWLEDGE' named entity 'VIRAL ENTRY' named entity 'PROKARYOTIC EXPRESSION' named entity 'CORE' named entity 'DRUGS TARGETING' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'FUSION' named entity 'COMBINED' named entity 'BUNDLE' named entity 'FILTRATION' named entity 'CORONAVIRUSES' named entity 'REPEAT' named entity 'SIMILAR' named entity 'HOST' named entity 'CAUSING' named entity 'FUSION' named entity 'GST' named entity 'HR2' named entity 'ECONOMIC LOSS' named entity 'ONE OF' named entity 'DOCUMENTED' named entity 'STRUCTURE' named entity 'TYPICAL' named entity 'DESTRUCTIVE' named entity 'PRESENTS' named entity 'HERE' named entity 'COILED-COIL' named entity 'CHEMICAL' named entity 'EVERY YEAR' named entity 'TRIMER' named entity 'BIOCHEMICAL' named entity 'ITS'

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