About: Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans
Creator	Weaver, Steven Kosakovsky Pond, Sergei Robertson, David Lytras, Spyros Maclean, Oscar Singer, Joshua
Source	BioRxiv; Medline; PMC; WHO
abstract	RNA viruses are proficient at switching to novel host species due to their fast mutation rates. Implicit in this assumption is the need to evolve adaptations in the new host species to exploit their cells efficiently. However, SARS-CoV-2 has required no significant adaptation to humans since the pandemic began, with no observed selective sweeps to date. Here we contrast the role of positive selection and recombination in the Sarbecoviruses in horseshoe bats to SARS-CoV-2 evolution in humans. While methods can detect some evidence for positive selection in SARS-CoV-2, we demonstrate these are mostly due to recombination and sequencing artefacts. Purifying selection is also substantially weaker in SARS-CoV-2 than in the related bat Sarbecoviruses. In comparison, our results show evidence for positive, specifically episodic selection, acting on the bat virus lineage SARS-CoV-2 emerged from. This signature of selection can also be observed among synonymous substitutions, for example, linked to ancestral CpG depletion on this bat lineage. We show the bat virus RmYN02 has recombinant CpG content in Spike pointing to coinfection and evolution in bats without involvement of other species. Our results suggest the non-human progenitor of SARS-CoV-2 was capable of human-human transmission as a consequence of its natural evolution in bats.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1101/2020.05.28.122366
bibo:pmid	32577659
has license	cc-by
sha1sum (hex)	e5609947afcf4f0a6ed13e540e249f07aeddc97c
schema:url	https://doi.org/10.1101/2020.05.28.122366
resource representing a document's title	Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans
has PubMed Central identifier	PMC7302214
has PubMed identifier	32577659
schema:publication	bioRxiv
resource representing a document's body	covid:e5609947afcf4f0a6ed13e540e249f07aeddc97c#body_text
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