About: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction

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About: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction
Creator	Antonakos, & Giamarellos-Bourboulis, E Antoniadou, E Gogos, & Ioakeimidou, A Kaziani, & Kontogiorgi, & Lassale, & Pagalou, E Prekates, & Psaroulis, &
source	PMC
abstract	How circulating inflammatory mediators change upon sepsis progression has not been studied. We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. Any increase of endocan was associated with worsening with odds ratio 16.65 (p < 0.0001). This increase was independently associated with progression into acute respiratory distress syndrome (ARDS) as shown after logistic regression analysis (odds ratio 2.91, p: 0.002). Changes of circulating cytokines do not mediate worsening of the critically ill patients. Instead endocan and Ang2 are increased and this may be interpreted as a key-playing role in the pathogenesis of ARDS and septic shock. Any increase of endocan is a surrogate of worsening of the clinical course.
has issue date	2017-04-28(xsd:dateTime)
bibo:doi	10.1007/s10096-017-2988-6
bibo:pmid	28455780
has license	no-cc
sha1sum (hex)	e636e15180f943ef7929d06c0188e496698d7691
schema:url	https://doi.org/10.1007/s10096-017-2988-6
resource representing a document's title	Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction
has PubMed Central identifier	PMC7101577
has PubMed identifier	28455780
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:e636e15180f943ef7929d06c0188e496698d7691#body_text
is schema:about of	named entity 'patients' named entity 'concentrations' named entity 'improvement' named entity 'measured' named entity 'prospective study' named entity 'circulating' named entity 'CIRCULATING' named entity 'MEDIATE' named entity 'ASSOCIATED WITH' named entity 'SEPSIS' named entity 'DYSFUNCTION' named entity 'odds ratio' named entity 'cytokines' named entity 'ARDS' named entity 'patients' named entity 'IL-8' named entity 'baseline' named entity 'patient' named entity 'acute respiratory distress syndrome (ARDS)' named entity 'Increase' named entity 'peptides' named entity 'ARDS' named entity 'septic shock' named entity 'Ang2' named entity 'regression analysis' named entity 'IFNγ' named entity 'ARDS' named entity 'IL-8' named entity 'angiopoietin-2' named entity 'follow-up' named entity 'pathogenesis' named entity 'systemic inflammatory response syndrome' named entity 'platelet count' named entity 'cytokine' named entity 'Ethics' named entity 'serum' named entity 'septic shock' named entity 'blood sampling' named entity 'SOFA score' named entity 'Department of Internal Medicine' named entity 'study protocol' named entity 'organ' named entity 'vasoactive' named entity 'ROC curve' named entity 'infection' named entity 'organ dysfunction' named entity 'peptides' named entity 'bacteremia' named entity 'ARDS' named entity 'organ dysfunction' named entity 'sepsis' named entity 'ICU' named entity 'host response' named entity 'sepsis' named entity 'centrifuged' named entity 'blood sampling' named entity 'SIRS' named entity 'San Diego' named entity 'kDa' named entity 'systemic inflammation' named entity 'septic shock' named entity 'blood sampling' named entity 'vascular permeability' named entity 'blood sample' named entity 'dry-ice' named entity 'IL-10' named entity 'ARDS' named entity 'regression analysis' named entity 'regression analysis' named entity 'DIC' named entity 'blood sampling'

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