About: An Intact Retroviral Gene Conserved in Spiny-Rayed Fishes for over 100 My

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About: An Intact Retroviral Gene Conserved in Spiny-Rayed Fishes for over 100 My Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Intact Retroviral Gene Conserved in Spiny-Rayed Fishes for over 100 My
Creator	Johnson, Welkin Gifford, Robert Henzy, Jamie Kenaley, Christopher
Source	Medline; PMC
abstract	We have identified a retroviral envelope gene with a complete, intact open reading frame (ORF) in 20 species of spiny-rayed fishes (Acanthomorpha). The taxonomic distribution of the gene, “percomORF”, indicates insertion into the ancestral lineage >110 Ma, making it the oldest known conserved gene of viral origin in a vertebrate genome. Underscoring its ancient provenence, percomORF exists as an isolated ORF within the intron of a widely conserved host gene, with no discernible proviral sequence nearby. Despite its remarkable age, percomORF retains canonical features of a retroviral glycoprotein, and tests for selection strongly suggest cooption for a host function. Retroviral envelope genes have been coopted for a role in placentogenesis by numerous lineages of mammals, including eutherians and marsupials, representing a variety of placental structures. Therefore percomORF’s presence within the group Percomorpha—unique among spiny-finned fishes in having evolved placentation and live birth—is especially intriguing.
has issue date	2016-12-30(xsd:dateTime)
bibo:doi	10.1093/molbev/msw262
bibo:pmid	28039384
has license	bronze-oa
sha1sum (hex)	e6cc1aee080a2a9a1b6818106c13a0cc24589b42
schema:url	https://doi.org/10.1093/molbev/msw262
resource representing a document's title	An Intact Retroviral Gene Conserved in Spiny-Rayed Fishes for over 100 My
has PubMed Central identifier	PMC5939848
has PubMed identifier	28039384
schema:publication	Molecular Biology and Evolution
resource representing a document's body	covid:e6cc1aee080a2a9a1b6818106c13a0cc24589b42#body_text
is schema:about of	named entity 'GENE' named entity 'RAYED' named entity 'making' named entity 'placental' named entity 'tests' named entity 'envelope' named entity 'Despite' named entity 'envelope' named entity '100' named entity 'PLACENTAL' named entity 'INCLUDING' named entity 'IDENTIFIED' named entity 'ORIGIN' named entity 'MAMMALS' named entity 'ORF' covid:arg/e6cc1aee080a2a9a1b6818106c13a0cc24589b42 named entity 'AGE' named entity 'SPINY' named entity 'RETROVIRAL' named entity 'HOST' named entity 'RETAINS' named entity 'SPECIES' named entity 'PERCOMORPHA' named entity 'PLACENTATION' named entity 'NUMEROUS' named entity 'GENES' named entity 'FISHES' named entity 'ENVELOPE' named entity 'STRUCTURES' named entity 'NEARBY' named entity 'GROUP' named entity 'COMPLETE' named entity 'PROVIRAL SEQUENCE' named entity 'OPEN READING FRAME' named entity 'DISTRIBUTION' named entity 'INTACT' named entity 'CONSERVED' named entity 'SPINY' named entity 'FEATURES' named entity 'UNDERSCORING' named entity 'MARSUPIALS' named entity 'UNIQUE' named entity 'VIRAL' named entity 'PRESENCE' named entity 'LINEAGE' named entity 'RETROVIRAL' named entity 'GENE' named entity 'INTACT' named entity 'FISHES' named entity 'KNOWN' named entity 'GENOME' named entity 'LIVE BIRTH' named entity 'INSERTION' named entity 'ROLE' named entity 'HAVE' named entity '27S' named entity 'INTRON' named entity 'GLYCOPROTEIN' named entity 'TESTS' named entity 'VERTEBRATE' named entity 'FUNCTION' named entity 'EVOLVED' named entity 'ISOLATED' named entity 'VARIETY' named entity 'CONSERVED' named entity 'ITS' named entity 'ANCIENT' named entity 'RETROVIRAL ENVELOPE GENE' named entity 'SUGGEST' named entity 'SELECTION' named entity 'mammals' named entity 'eutherians' named entity 'insertion' named entity 'features' named entity 'retains' named entity 'retroviral' named entity 'species' named entity 'retroviral'

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