About: Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria
Creator	Sivapalasingam, Sumathi Eichenberger, Emily Park, Lawrence Dagher, Michael Fowler, Vance Hersh, Lisa Prasad, Brinda Ruffin, Felicia
Source	PMC
abstract	The complement system is a vital component of the innate immune system, though its role in bacteremia is poorly understood. We present complement levels in Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) and describe observed associations of complement levels with clinical outcomes. Complement and cytokine levels were measured in serum samples from 20 hospitalized patients with SAB, 20 hospitalized patients with GNB, 10 non-infected hospitalized patients, and 10 community controls. C5a levels were significantly higher in patients with SAB as compared to patients with GNB. Low C4 and C3 levels were associated with septic shock and 30-day mortality in patients with GNB, and elevated C3 was associated with a desirable outcome defined as absence of (1) septic shock, (2) acute renal failure, and (3) death within 30 days of bacteremia. Low levels of C9 were associated with septic shock in patients with GNB but not SAB. Elevated IL-10 was associated with increased 30-day mortality in patients with SAB. Complement profiles differ in patients with SAB and those with GNB. Measurement of IL-10 in patients with SAB and of C4, C3, and C9 in patients with GNB may help to identify those at higher risk for poor outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-020-03955-z) contains supplementary material, which is available to authorized users.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.1007/s10096-020-03955-z
has license	no-cc
sha1sum (hex)	e6df0c3bb8c5eba93148e28b00ca46458503f160
schema:url	https://doi.org/10.1007/s10096-020-03955-z
resource representing a document's title	Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria
has PubMed Central identifier	PMC7334117
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:e6df0c3bb8c5eba93148e28b00ca46458503f160#body_text
is schema:about of	named entity 'patients' named entity 'patients' named entity 'higher' named entity 'levels' named entity 'associations' named entity 'hospitalized' named entity 'ROLE' named entity 'CONTROLS' named entity '283' named entity 'INCREASED' named entity 'LOW' named entity 'patients' named entity 'bacteremia' named entity 'mortality' named entity 'measured' named entity 'patients' named entity 'describe' named entity 'Elevated' named entity 'bacteremia' named entity 'patients' named entity 'controls' named entity 'levels' named entity 'Staphylococcus aureus' named entity 'complement' named entity 'complement' named entity 'Complement' named entity 'bloodstream infection' named entity 'Complement' named entity 'Gram-negative bacteria' named entity 'Staphylococcus aureus' named entity 'agarose' named entity 'infection' named entity 'C5b' named entity 'acute renal failure' named entity 'IL-4' named entity '1, 2' named entity 'turbidity' named entity 'Statistical significance' named entity 'complement pathway' named entity 'antibodies' named entity 'mTOR inhibitors' named entity 'control groups' named entity 'IL-5' named entity 'glomerular basement membrane' named entity 'IL-10' named entity 'complement cascade' named entity 'bacteremic' named entity 'inflammatory response' named entity 'complement' named entity 'ANCA vasculitis' named entity 'neoplasm' named entity 'Complement' named entity 'Staphylococcus aureus' named entity 'Kruskal-Wallis test' named entity 'monoclonal antibodies' named entity 'complement' named entity 'septic shock' named entity 'cytokine' named entity 'fluorescent' named entity 'multi-organ failure' named entity 'IL-8' named entity 'competitive binding' named entity 'electronic medical record' named entity 'immunosuppressive therapy' named entity 'IL-5' named entity 'IL-6' named entity 'control group' named entity 'IL-12p70' named entity 'control groups' named entity 'immunosuppressive agent' named entity 'complement' named entity 'TNF-α' named entity 'cecal' named entity '1.000' named entity 'bacteremia' named entity 'deficient mice'

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