About: Multi-biomarker responses to pesticides in an agricultural population from Central Brazil

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multi-biomarker responses to pesticides in an agricultural population from Central Brazil
Creator	Batista, Renata Borges De Almeida, Frankcione De Melo E Silva, Daniela De Melo, Daniela Francelin, Carolina Godoy, Fernanda Millena, Thays Pedroso, Alves Ramos, Aguiar Ribeiro, Francis Rocha-Parise, Michelle Sonara, Jheneffer
Source	Elsevier; PMC
abstract	Abstract We evaluated farmworkers exposed to pesticides and individuals with no history of occupational exposure to pesticides. It was performed the comet assay to evaluate DNA damage. The immunophenotyping of TCD4+ lymphocyte subpopulations in peripheral blood was performed by flow cytometry. The single nucleotide polymorphisms (SNPs) in PON1, XRCC1, IL6, IL6R, TNF-α, and MIR137 genes were evaluated by real-time PCR. The exposed group was composed mostly by males (69.44%), with direct exposure to pesticides (56%) and with an average age range of 46 ± 13.89 years, being that 58.3% of farmworkers directly exposed to pesticides and reported the full use of personal protective equipment (PPE). DNA damage was greater in the exposed group (p < 0.05), reinforced by the use of PPE to denote a lower degree of DNA damage (p = 0.002). In this context, in the exposed group, we demonstrated that the use of PPE, age, gender and intoxication events were the variables that most contributed to increase DNA damage (p < 0.0001). Besides, the exposed group showed a significant increase in the subpopulations of T lymphocytes CD3+ CD4+ (p = 0.04) and CD3+ CD4+ CD25+ (p < 0.0001). SNPs in the TNF-α (rs361525) gene presented a difference in the genotype distribution between the groups (p = 0.002). The genotype distribution of TNF-α (rs361525) was also positively correlated with the DNA damage of the exposed group (r = 0.19; p = 0.01), demonstrating a higher risk of DNA damage in the farmworkers presenting the A mutated allele. Our findings demonstrate that pesticides can exert various deleterious effects on human health by damaging the DNA as well as by influencing the immune system in the case of both direct or indirect exposure and these issues are associated to age, gender, intoxication and the nonuse of PPE.
has issue date	2020-08-21(xsd:dateTime)
bibo:doi	10.1016/j.scitotenv.2020.141893
has license	els-covid
sha1sum (hex)	e8189566bea3deb42454610e32e39c843297bf34
schema:url	https://doi.org/10.1016/j.scitotenv.2020.141893
resource representing a document's title	Multi-biomarker responses to pesticides in an agricultural population from Central Brazil
has PubMed Central identifier	PMC7441936
schema:publication	Sci Total Environ
resource representing a document's body	covid:e8189566bea3deb42454610e32e39c843297bf34#body_text
is schema:about of	named entity 'population' named entity 'pesticides' named entity 'Brazil' named entity 'BIOMARKER' named entity 'PESTICIDES' named entity 'XRCC1' named entity 'CD4' named entity 'CD4' named entity 'CD4' named entity 'morphologically' named entity 'FoxP3' named entity 'positive correlation' named entity 'pesticides' named entity 'epidemiological' named entity 'CD4' named entity 'p-value' named entity 'genotoxic' named entity 'pesticide' named entity 'well-mixed' named entity 'PON1' named entity 'DNA damage' named entity 'autophagy' named entity 'IL6' named entity 'DNA damage' named entity 'Hardy-Weinberg Equilibrium' named entity 'pesticide' named entity 'genotoxic' named entity 'oxidative stress' named entity 'CD25' named entity '0.01' named entity 'psychiatric problems' named entity 'statistically significant' named entity 'necrosis' named entity 'DNA repair' named entity 'pesticide' named entity 'ubiquitin protease' named entity 'PPE' named entity 'DNA damage' named entity 'pesticides' named entity 'immune response' named entity 'genotypes' named entity 'genotyping' named entity 'single cell' named entity 'thyroid disease' named entity 'regulatory T cells' named entity 'rs1800795' named entity 'genotype frequencies' named entity 'GSTT1' named entity 'PON1' named entity 'Ficoll' named entity 'regulatory T cells' named entity 'pesticide' named entity 'pesticide' named entity 'insecticide' named entity 'oxidative stress' named entity 'Allele' named entity 'lymphocytes' named entity 'IL6' named entity 'Specchia' named entity 'genotoxic' named entity 'SNPs' named entity 'lymphocytes' named entity 'pesticides' named entity 'GSTM1' named entity 'proinflammatory cytokine' named entity 'control group' named entity 'biomarkers' named entity 'genotoxic' named entity 'genotoxicity' named entity 'immunotoxicity' named entity 'DNA damage' named entity 'pesticide poisoning'

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