About: Expression of a selenomethionyl derivative and preliminary crystallographic studies of human cystatin C

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expression of a selenomethionyl derivative and preliminary crystallographic studies of human cystatin C
Creator	Janowski, Robert Grubb, Anders Grzonka, Zbigniew Jaskolski, Mariusz Abrahamson, Magnus Fernandez, Marcia Jankowska, Elzbieta Kozak, Maciej
source	Medline; PMC
abstract	Human cystatin C, a protein with amyloidogenic properties and a potent inhibitor of papain‐like mammalian proteases, has been produced in its full‐length form by recombinant techniques and crystallized in two polymorphic forms: cubic and tetragonal. A selenomethionyl derivative of the protein, obtained by Escherichia coli expression and with complete Met→Se‐Met substitution confirmed by mass spectrometry, amino‐acid analysis and X‐ray absorption spectra, was crystallized in the cubic form. A truncated variant of the protein, lacking ten N‐terminal residues, has also been crystallized. The crystals of this variant are tetragonal and, like the two polymorphs of the full‐length protein, contain multiple copies of the molecule in the asymmetric unit, suggesting oligomerization of the protein.
has issue date	2007-09-27(xsd:dateTime)
bibo:doi	10.1107/s090744499901121x
bibo:pmid	10531502
has license	no-cc
sha1sum (hex)	ea8d90b44f0f85f0f495de8b6ee5ebadf994c29d
schema:url	https://doi.org/10.1107/s090744499901121x
resource representing a document's title	Expression of a selenomethionyl derivative and preliminary crystallographic studies of human cystatin C
has PubMed Central identifier	PMC7161602
has PubMed identifier	10531502
schema:publication	Acta Crystallogr D Biol Crystallogr
resource representing a document's body	covid:ea8d90b44f0f85f0f495de8b6ee5ebadf994c29d#body_text
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