About: Coronavirus glycoprotein E1, a new type of viral glycoprotein

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About: Coronavirus glycoprotein E1, a new type of viral glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronavirus glycoprotein E1, a new type of viral glycoprotein
Creator	Niemann, H Klenk, H.-D
topic	covid:eac150173aec2d126e80d933621ebcb4f67f1968#this
source	Elsevier; Medline; PMC
abstract	Abstract The carbohydrate contents of coronavirus glycoproteins E1 and E2 have been analyzed. E2 has complex and mannose-rich-type oligosaccharide side-chains, which are attached by N-glycosidic linkages to the polypeptide. Glycosylation of E2 is initiated at the co-translational level, and it is inhibited by tunicamycin, 2-deoxy-glucose, and 2-deoxy-2-fluoro-glucose. Thus, E2 belongs to a glycoprotein type found in many other enveloped viruses. E1, in contrast, represents a different class of glycoprotein. The following observations indicate that its carbohydrate side-chains have 0-glycosidic linkage. (1) The constituent sugars of E1 are N-acetylglucosamine, N-acetylgalactosamine, galactose, and neuraminic acid; mannose and fucose are absent. (2) The side-chains can be removed by β-elimination. (3) Glycosylation of E1 is not sensitive to the compounds interfering with N-glycosylation. E1 is the first viral glycoprotein analyzed that contains only 0-glycosidic linkages. Coronaviruses are therefore a suitable model system to study biosynthesis and processing of this type of glycoprotein.
has issue date	1981-12-25(xsd:dateTime)
bibo:doi	10.1016/0022-2836(81)90463-0
bibo:pmid	7343686
has license	els-covid
sha1sum (hex)	eac150173aec2d126e80d933621ebcb4f67f1968
schema:url	https://doi.org/10.1016/0022-2836%2881%2990463-0
resource representing a document's title	Coronavirus glycoprotein E1, a new type of viral glycoprotein
has PubMed Central identifier	PMC7130891
has PubMed identifier	7343686
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:eac150173aec2d126e80d933621ebcb4f67f1968#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/eac150173aec2d126e80d933621ebcb4f67f1968
is schema:about of	named entity 'linkages' named entity 'side-chains' named entity 'RICH' named entity 'HAVE' named entity 'INHIBITED' named entity 'COMPLEX' named entity 'MANNOSE' named entity 'DEOXY' named entity 'OLIGOSACCHARIDE' named entity 'CONTENTS' named entity 'GLUCOSE' named entity 'GLYCOPROTEINS' named entity 'LEVEL' named entity 'GLYCOSYLATION' named entity 'POLYPEPTIDE' named entity 'TUNICAMYCIN' named entity 'TYPE' named entity 'ATTACHED' named entity 'VIRAL GLYCOPROTEIN' named entity 'GLYCOPROTEIN' named entity 'NEW TYPE' named entity 'CHAINS' named entity 'FLUORO' named entity 'CARBOHYDRATE' named entity 'TRANSLATIONAL' named entity 'CORONAVIRUS' named entity 'CORONAVIRUS' named entity 'ANALYZED' covid:arg/eac150173aec2d126e80d933621ebcb4f67f1968 named entity 'Glycosylation' named entity 'polypeptide' named entity 'glycoproteins' named entity 'side-chains' named entity 'carbohydrate' named entity 'coronavirus' named entity 'glucose' named entity 'Glycoprotein' named entity 'paramyxoviruses' named entity 'murine coronavirus' named entity 'fatty acid' named entity 'Bayer AG' named entity 'aqueous' named entity 'amino acids' named entity 'glycoproteins' named entity 'enzyme' named entity 'enzyme' named entity 'SDS' named entity 'plasma membrane' named entity 'coronavirus' named entity 'carbohydrate' named entity 'alphaviruses' named entity 'glycosylated' named entity 'side-chains' named entity 'w/v' named entity 'Amino acid' named entity 'glycopeptides' named entity 'eluted' named entity '80 minutes' named entity 'Glycoprotein' named entity 'glycosylation' named entity 'distilled water' named entity 'side-chains' named entity 'fluoro' named entity 'molecular weight' named entity 'Germany' named entity 'carbohydrate' named entity 'Stohlman' named entity '90,000' named entity 'polypeptides' named entity 'Triton X-100' named entity 'cleavage' named entity 'oligosaccharides' named entity 'serum' named entity 'glyco' named entity 'fused silica' named entity 'solubility' named entity 'glycoprotein' named entity 'glycoproteins'

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