About: Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

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About: Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
Creator	Karlberg, Tobias Langelier, Marie-France Schüler, Herwig Pascal, John
topic	covid:eaf98af4dfebe470f8ac7b99608aebb4553dc5a2#this
Source	Elsevier; Medline; PMC
abstract	ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.
has issue date	2013-12-01(xsd:dateTime)
bibo:doi	10.1016/j.mam.2013.02.002
bibo:pmid	23458732
has license	green-oa
sha1sum (hex)	eaf98af4dfebe470f8ac7b99608aebb4553dc5a2
schema:url	https://doi.org/10.1016/j.mam.2013.02.002
resource representing a document's title	Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
has PubMed Central identifier	PMC3726583
has PubMed identifier	23458732
schema:publication	Molecular Aspects of Medicine
resource representing a document's body	covid:eaf98af4dfebe470f8ac7b99608aebb4553dc5a2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/eaf98af4dfebe470f8ac7b99608aebb4553dc5a2
is schema:about of	named entity 'DNA repair' named entity 'biology' named entity 'TRANSCRIPTION CONTROL' named entity 'S T' named entity 'DETAILED' named entity 'INVOLVED' named entity 'REVIEW' named entity 'SMALL MOLECULE' named entity 'ADP-RIBOSYLATION' named entity 'READERS' named entity 'STRUCTURES' named entity 'MONO' named entity 'SIGNALING' named entity 'RIBOSE' named entity 'MEDIATED' named entity 'WRITERS' named entity 'POLY' named entity 'ACTIVITIES' named entity 'DEVELOPMENT' named entity 'READERS' named entity 'STRUCTURAL BIOLOGY' named entity 'SINGLE' named entity 'HELP' named entity 'PROVIDE' named entity 'THERAPEUTIC' named entity 'VARIOUS' named entity 'UNDERSTAND' named entity 'HAVE' named entity 'PROTEINS' named entity 'PROTEIN CRYSTAL' named entity 'RECENT' named entity 'STATES' named entity 'DNA REPAIR' named entity 'WRITERS' named entity 'INCLUDING' named entity 'STRUCTURAL BIOLOGY' named entity 'PROTEIN DEGRADATION' named entity 'UNDERSTANDING' named entity 'PROCESSES' named entity 'PROTEIN ' named entity 'BIOLOGICAL FUNCTIONS' named entity 'DISEASE' named entity 'ANALYSIS' named entity 'MODULATING' named entity 'ORGANELLE ASSEMBLY' named entity 'HERE' named entity 'CHROMATIN ORGANIZATION' named entity 'OUR' named entity 'BASIS' named entity 'BENEFITS' covid:arg/eaf98af4dfebe470f8ac7b99608aebb4553dc5a2 named entity 'small molecule' named entity 'organelle' named entity 'protein' named entity 'metabolism' named entity 'PARP1' named entity 'magnesium' named entity 'Tankyrase' named entity 'physiological functions' named entity 'base stacking' named entity 'binding region' named entity 'ankyrin repeat' named entity 'N-terminus' named entity 'tankyrase' named entity 'ADP' named entity 'DNA damage' named entity 'SAM' named entity 'ribose' named entity 'DNA damage' named entity 'tankyrases' named entity 'DNA damage' named entity 'WGR' named entity 'tankyrase' named entity 'therapeutic agents' named entity 'SAM' named entity 'PARP inhibitors'

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