About: Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia

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About: Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia
Creator	Mustaffa-Kamal, Farina Manoraj, Hemadevy Rahman Omar, Abdul Selvarajah, Gayathri Tan, Wei Hidayah, Nur Hua Khor, Kuan Husna Omar, Nurul Isa, Mohd
Source	Elsevier; Medline; PMC
abstract	Feline morbillivirus (FeMV), a novel virus from the family of Paramyxoviridae, was first identified in stray cat populations. The objectives of the current study were to (i) determine the molecular prevalence of FeMV in Malaysia; (ii) identify risk factors associated with FeMV infection; and (iii) characterise any FeMV isolates by phylogenetic analyses. Molecular analysis utilising nested RT-PCR assay targeting the L gene of FeMV performed on either urine, blood and/or kidney samples collected from 208 cats in this study revealed 82 (39.4%) positive cats. FeMV-positive samples were obtained from 63/124 (50.8%) urine and 20/25 (80.0%) kidneys while all blood samples were negative for FeMV. In addition, from the 35 cats that had more than one type of samples collected (blood and urine; blood and kidney; blood, urine and kidney), only one cat had FeMV RNA in the urine and kidney samples. Risk factors such as gender, presence of kidney-associated symptoms and cat source were also investigated. Male cats had a higher risk (p = 0.031) of FeMV infection than females. In addition, no significant association (p = 0.083) was observed between the presence of kidney-associated symptoms with FeMV status. From the 82 positive samples, FeMV RNA was detected from 48/82 (58.5%) pet cats and 34/126 (27.0%) shelter cats (p < 0.0001). Partial L and N gene sequencing of the RT-PCR-positive samples showed 85–99% identity to the published FeMV sequences and it was significantly different from all other morbilliviruses. A phylogenetic analysis of the identified Malaysian FeMVs was performed with isolates from Japan, Thailand and China. Molecular characterisation revealed high relatedness of the Malaysian isolates with other Asian FeMVs, indicating that the virus had been circulating only within the region. Therefore, this study confirmed the existence of FeMV among domestic cats in Malaysia. The findings suggest further characterisation of the local isolates, including the whole genome sequencing and that studies at determining the direct consequences of FeMV infection in domestic cats are needed.
has issue date	2019-08-09(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.08.005
bibo:pmid	31500720
has license	no-cc
sha1sum (hex)	ed7aaaa3c76a89ccb76c68472f9a3103580efc0c
schema:url	https://doi.org/10.1016/j.vetmic.2019.08.005
resource representing a document's title	Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia
has PubMed Central identifier	PMC7117105
has PubMed identifier	31500720
schema:publication	Vet Microbiol
resource representing a document's body	covid:ed7aaaa3c76a89ccb76c68472f9a3103580efc0c#body_text
is schema:about of	named entity 'DOMESTIC' named entity 'determine' named entity 'kidney' named entity 'urine' named entity 'molecular' named entity 'MOLECULAR' named entity 'CATS' named entity 'BLOOD' named entity 'CAT' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RT-PCR ASSAY' named entity 'SAMPLES' named entity 'SOURCE' named entity 'MALAYSIA' named entity 'MORBILLIVIRUSES' named entity 'FEMALES' named entity 'NEGATIVE' named entity 'DIFFERENT' named entity 'ISOLATES' named entity 'N GENE' named entity 'PRESENCE OF' named entity 'RNA' named entity 'PARTIAL' named entity 'MOLECULAR' named entity 'EITHER' named entity 'PREVALENCE' named entity 'VIRUS' named entity 'CURRENT' named entity 'POPULATIONS' named entity 'SIGNIFICANT' named entity 'INVESTIGATED' named entity 'INFECTION' named entity 'OBTAINED' named entity '28I' named entity 'CATS' named entity '20%' named entity 'FELINE MORBILLIVIRUS' named entity 'TARGETING' named entity 'POSITIVE' named entity 'STATUS' named entity 'SEQUENCES' named entity 'PUBLISHED' named entity 'COLLECTED' named entity 'ASSOCIATED WITH' named entity 'IDENTIFY' named entity 'BLOOD SAMPLES' named entity 'IDENTIFIED' named entity 'FAMILY' named entity 'PERFORMED' named entity 'TYPE' named entity 'ASSOCIATED SYMPTOMS' named entity 'MALE' named entity 'MALAYSIAN' named entity 'ASSOCIATION' named entity '2880' named entity 'FELINE MORBILLIVIRUS' named entity 'PARAMYXOVIRIDAE' named entity 'JAPAN' named entity 'SHELTER' named entity 'REVEALED' named entity '0.083' named entity 'STUDY' named entity 'IDENTITY' named entity 'NOVEL' named entity 'OBJECTIVES' named entity 'DETERMINE' named entity 'RT-PCR' named entity '0.031' named entity 'MOLECULAR ANALYSIS' named entity '208' named entity 'NESTED' named entity 'PET' named entity '28P'

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