About: The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report

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About: The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report
Creator	Chen, Li Li, Jianming Liu, Yingxia Peng, Ling Wang, Fuxiang Yuan, Jing Yang, Liang Jiang, Xiao Wu, Weibo Cao, Mengli Cai, Zhao Chen, Chuming Feng, Shiyan Li, Yinfeng Zhang, Peiyan
source	Medline; PMC
abstract	BACKGROUND: The novel coronavirus disease 2019 (COVID-19) outbreak started in Wuhan, Hubei, China since Dec 2019 and cases of infection have been continuously reported in various countries. It is now clear that the SARS-COV-2 coronavirus is transmissible from human to human. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. In this case report, we describe our experience in detection of SARS-COV-2 from a confirmed patient using nucleic acid test of bronchoalveolar-lavage fluid (BALF) samples but not nasopharyngeal swabs. CASE PRESENTATION: We present a case of severely ill SARS-COV-2 infected 46-year-old man with fever, coughing and chest tightness. We performed viral detection using his BALF samples and imaging method (CT) for confirmation. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. The patient was cured and discharged. CONCLUSION: This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1186/s12879-020-05045-z
bibo:pmid	32354369
has license	cc-by
sha1sum (hex)	edc65ac984b83d5b47d49f52e492163549685b4e
schema:url	https://doi.org/10.1186/s12879-020-05045-z
resource representing a document's title	The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report
has PubMed Central identifier	PMC7191555
has PubMed identifier	32354369
schema:publication	BMC Infect Dis
resource representing a document's body	covid:edc65ac984b83d5b47d49f52e492163549685b4e#body_text
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