About: Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
Creator	Collin, Mattias Valentin-Weigand, Peter Hammerschmidt, Sven Kreikemeyer, Bernd Oehmcke-Hecht, Sonja Siemens, Nikolai Chaussee, Michael Mettenleiter, Thomas
source	PMC
abstract	Bacterial and viral co-infections of the respiratory tract are life-threatening and present a global burden to the global community. Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes are frequent colonizers of the upper respiratory tract. Imbalances through acquisition of seasonal viruses, e.g., Influenza A virus, can lead to bacterial dissemination to the lower respiratory tract, which in turn can result in severe pneumonia. In this review, we summarize the current knowledge about bacterial and viral co-infections of the respiratory tract and focus on potential experimental models suitable for mimicking this disease. Transmission of IAV and pneumonia is mainly modeled by mouse infection. Few studies utilizing ferrets, rats, guinea pigs, rabbits, and non-human primates are also available. The knowledge gained from these studies led to important discoveries and advances in understanding these infectious diseases. Nevertheless, mouse and other infection models have limitations, especially in translation of the discoveries to humans. Here, we suggest the use of human engineered lung tissue, human ex vivo lung tissue, and porcine models to study respiratory co-infections, which might contribute to a greater translation of the results to humans and improve both, animal and human health.
has issue date	2017-12-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.02602
bibo:pmid	29312268
has license	cc-by
sha1sum (hex)	ee0050c6fb81a4067d134010d0c80d21edb5df0b
schema:url	https://doi.org/10.3389/fmicb.2017.02602
resource representing a document's title	Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
has PubMed Central identifier	PMC5742597
has PubMed identifier	29312268
schema:publication	Front Microbiol
resource representing a document's body	covid:ee0050c6fb81a4067d134010d0c80d21edb5df0b#body_text
is schema:about of	named entity 'Transmission' named entity 'bacterial' named entity 'Bacterial' named entity 'non-human primates' named entity 'infection' named entity 'models' named entity 'Streptococcus' named entity 'Port' named entity 'Does' named entity 'CONTRIBUTE ' named entity 'ENGINEERED' named entity 'MODELS' named entity 'PRIMATES' named entity 'GAINED' named entity 'RESULTS' named entity 'TRANSLATION' named entity 'TRANSMISSION' named entity 'REVIEW' named entity 'EXPERIMENTAL MODELS' named entity 'SEVERE PNEUMONIA' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'UNDERSTANDING' named entity 'VIRAL' named entity 'CURRENT' named entity 'LUNG TISSUE' named entity 'RABBITS' named entity 'BURDEN' named entity 'FERRETS' named entity 'LED' named entity 'HAVE' named entity 'DISSEMINATION' named entity 'INFECTIOUS DISEASES' named entity 'GUINEA PIGS' named entity 'LOWER RESPIRATORY TRACT' named entity 'EX VIVO' named entity 'SUGGEST' named entity 'POTENTIAL' named entity 'DISEASE' named entity 'VIRUSES' named entity 'LIFE' named entity 'IMPORTANT' named entity 'STREPTOCOCCUS PYOGENES' named entity 'FOCUS' named entity 'MOUSE' named entity 'COMMUNITY' named entity 'BACTERIAL' named entity 'DOES' named entity 'PORCINE' named entity 'CO-INFECTIONS' named entity 'FREQUENT' named entity 'NON-' named entity 'RESULT' named entity 'THESE' named entity 'HUMAN' named entity 'ACQUISITION' named entity 'RESPIRATORY INFECTIONS' named entity 'LEAD' named entity 'INFLUENZA A VIRUS' named entity 'BACTERIA' named entity 'PORT' named entity 'GLOBAL' named entity 'USE OF' named entity 'ANIMAL' named entity 'PRESENT' named entity 'RESPIRATORY' named entity 'ABOUT' named entity 'LIMITATIONS' named entity 'SUITABLE' named entity 'INFLUENZA A VIRUS' named entity 'PAVE' named entity 'INFECTION' named entity 'HUMAN HEALTH' named entity 'RATS' named entity 'AVAILABLE'

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