About: Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region

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About: Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region
Creator	Spencer, Kelly-Anne Hiscox, Julian
source	Elsevier; Medline; PMC
abstract	Abstract The coronavirus nucleocapsid (N) protein binds viral RNA to form the ribonucleocapsid and regulate RNA synthesis. The interaction of N protein with viral RNA was investigated using circular dichroism and surface plasmon resonance. N protein underwent a conformational change upon binding viral RNA and the data indicated electrostatic interactions were involved in the binding of the protein to RNA. Kinetic analysis suggested the amino-terminal region facilitates long-range non-specific interactions between N protein and viral RNA, thus bringing the RNA into close proximity to N protein allowing specific contacts to form via a ‘lure’ and ‘lock’ mechanism.
has issue date	2006-10-30(xsd:dateTime)
bibo:doi	10.1016/j.febslet.2006.09.052
bibo:pmid	17052713
has license	els-covid
sha1sum (hex)	ee0ae3e80679966a71eaeb8ecefb4ff3970ec4f7
schema:url	https://doi.org/10.1016/j.febslet.2006.09.052
resource representing a document's title	Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region
has PubMed Central identifier	PMC7094245
has PubMed identifier	17052713
schema:publication	FEBS Letters
resource representing a document's body	covid:ee0ae3e80679966a71eaeb8ecefb4ff3970ec4f7#body_text
is schema:about of	named entity 'binding' named entity 'suggested' named entity 'proximity' covid:arg/ee0ae3e80679966a71eaeb8ecefb4ff3970ec4f7 named entity 'VIRAL RNA' named entity 'CORONAVIRUS' named entity 'NUCLEOCAPSID PROTEIN' named entity 'RNA' named entity 'INTERACTIONS' named entity 'INVESTIGATED' named entity 'PROTEIN ' named entity 'SURFACE PLASMON RESONANCE' named entity 'PROXIMITY' named entity 'RANGE' named entity 'CIRCULAR DICHROISM' named entity 'KINETIC' named entity 'BINDS' named entity 'NON-SPECIFIC' named entity 'USING' named entity 'REGION' named entity 'REGULATE' named entity 'INTERACTION' named entity 'CONFORMATIONAL CHANGE' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'RNA BINDING' named entity 'MECHANISM' named entity 'PROPERTIES' named entity 'PROTEIN ' named entity 'REGION' named entity 'TERMINAL' named entity 'TERMINAL' named entity 'AMINO' named entity 'INVOLVED' named entity 'INDICATED' named entity 'ANALYSIS' named entity 'CORONAVIRUS' named entity 'BINDING' named entity 'SPECIFIC' named entity 'CLOSE' named entity 'ALLOWING' named entity 'LONG' named entity 'AMINO' named entity 'DATA' named entity 'CONTACTS' named entity 'ELECTROSTATIC' named entity 'N PROTEIN' named entity 'TO FORM' named entity 'RNA SYNTHESIS' named entity 'NUCLEOCAPSID' named entity 'viral' named entity 'electrostatic interactions' named entity 'viral' named entity 'protein' named entity 'data' named entity 'viral' named entity 'The' named entity 'RNA' named entity 'protein' named entity 'surface plasmon' named entity 'interaction' named entity 'amino-terminal' named entity 'nucleocapsid' named entity 'electrostatic interactions' named entity 'protein' named entity 'viral RNA' named entity 'nucleocapsid' named entity 'nucleocapsid' named entity 'nucleocapsid' named entity 'protein' named entity 'infectious bronchitis virus' named entity 'coronavirus' named entity 'protein' named entity 'mass spectroscopy' named entity 'polyadenylated' named entity 'RNA' named entity 'positive sense' named entity 'conformation' named entity '10.4' named entity 'RNA/protein interactions' named entity 'coding region'

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