About: Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays

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About: Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays
Creator	Steinmann, Joerg Fiedler, Melanie Liebregts, Tobias Wohlfarth, Philipp Beelen, Dietrich Steckel, Nina Turki, Amin
Source	Elsevier; Medline; PMC
abstract	Allogeneic hematopoietic stem cell transplantation (HSCT) recipients frequently develop acute respiratory failure (ARF) with pulmonary infiltrates. Molecular- and biomarker-based assays enhance pathogen detection, but data on their yield in this population are scarce. This was a retrospective single-center study of 156 consecutive HSCT recipients admitted to the intensive care unit (ICU) between May 2013 and July 2017. Findings from a microbiologic diagnostic workup using currently available methods on bronchoalveolar lavage (BAL) and blood samples from 66 patients (age, 58 years [range, 45 to 64]; HSCT to ICU, 176 days [range, 85 to 407]) with ARF and pulmonary infiltrates were analyzed. In 47 patients (71%) a causative pathogen was identified (fungal, n = 28; viral, n = 26; bacterial, n = 18). Polymicrobial findings involving several pathogen groups occurred in 20 patients (30%). Culture (12/16, 75%), galactomannan (13/15, 87%), and Aspergillus-PCR (8/9, 89%) from BAL but not serum galactomannan (6/14, 43%) helped to diagnose invasive aspergillosis (n = 16, 24%). Aspergillus-PCR detected azole resistance in 2 cases. Mucorales was found in 7 patients (11%; BAL culture, n = 6; Mucorales-PCR, n = 1). Patients with identified pathogens had higher Simplified Acute Physiology Score II scores (P = .049) and inferior ICU survival (6% versus 37%, P < .01), which largely related to the presence of an invasive fungal infection. Eight patients (12%) had 1 or more viruses with uncertain lung pathogenicity as the sole microbiologic finding. A diagnostic microbiologic workup incorporating molecular- and biomarker-based assays identified pathogens in most HSCT recipients with ARF and pulmonary infiltrates admitted to the ICU. Implications of polymicrobial infection and pathogen patterns in these patients warrant further investigation.
has issue date	2018-03-14(xsd:dateTime)
bibo:doi	10.1016/j.bbmt.2018.03.007
bibo:pmid	29550627
has license	no-cc
sha1sum (hex)	ee3f9354a18ef0a9720d248833edcc34617b9dc8
schema:url	https://doi.org/10.1016/j.bbmt.2018.03.007
resource representing a document's title	Microbiologic Diagnostic Workup of Acute Respiratory Failure with Pulmonary Infiltrates after Allogeneic Hematopoietic Stem Cell Transplantation: Findings in the Era of Molecular- and Biomarker-Based Assays
has PubMed Central identifier	PMC7110883
has PubMed identifier	29550627
schema:publication	Biol Blood Marrow Transplant
resource representing a document's body	covid:ee3f9354a18ef0a9720d248833edcc34617b9dc8#body_text
is schema:about of	named entity 'galactomannan' named entity 'ARF' named entity 'scores' named entity 'bronchoalveolar lavage' named entity 'ICU' named entity 'pulmonary' named entity 'causative' named entity 'Era' named entity 'SURVIVAL' named entity 'PATHOGENS' named entity 'AZOLE' named entity 'BLOOD SAMPLES' named entity 'HSCT' named entity 'YIELD' named entity 'INVESTIGATION' named entity 'CULTURE' named entity 'UNCERTAIN' named entity 'DIAGNOSTIC' named entity 'DATA' named entity 'FOUND' named entity 'PATTERNS' named entity 'ICU' named entity 'ADMITTED TO' named entity 'DETECTED' named entity 'BASED' named entity 'JULY' named entity 'DAYS' named entity 'BAL' named entity 'POLYMICROBIAL INFECTION' named entity 'PCR' named entity 'SOLE' named entity 'IDENTIFIED' named entity 'FINDINGS' named entity '1 OR MORE' named entity 'RETROSPECTIVE' named entity 'RELATED' named entity 'METHODS' named entity 'PATHOGEN' named entity 'INVASIVE FUNGAL INFECTION' named entity 'VIRAL' named entity '288' named entity 'S T' named entity 'OCCURRED' named entity 'INVASIVE ASPERGILLOSIS' named entity 'HIGHER' named entity 'STUDY' named entity 'PATHOGENICITY' named entity 'RESISTANCE' named entity 'AVAILABLE' named entity 'SINGLE' named entity 'FINDING' named entity 'PATIENTS' named entity 'GROUPS' named entity 'INFERIOR' named entity '156' named entity 'INVOLVING' named entity 'ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION' named entity 'SCORES' named entity 'LARGELY' named entity 'THEIR' named entity 'INTENSIVE CARE UNIT' named entity 'BACTERIAL' named entity 'GALACTOMANNAN' named entity 'FINDINGS' named entity 'PULMONARY INFILTRATES' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'ERA' named entity 'BASED' named entity 'THESE' named entity 'BUT' named entity 'ANALYZED' named entity 'MUCORALES' named entity 'ARF' named entity 'ENHANCE' named entity 'MOLECULAR'

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