About: Deubiquitylating Enzymes and DNA Damage Response Pathways

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Deubiquitylating Enzymes and DNA Damage Response Pathways
Creator	Jacq, Xavier Kemp, Mark Jackson, S Jackson, Stephen Jackson, Á Jacq, X Kemp, Á Martin, Niall Martin, Á
Source	PMC
abstract	Covalent post-translational modification of proteins by ubiquitin and ubiquitin-like factors has emerged as a general mechanism to regulate myriad intra-cellular processes. The addition and removal of ubiquitin or ubiquitin-like proteins from factors has recently been demonstrated as a key mechanism to modulate DNA damage response (DDR) pathways. It is thus, timely to evaluate the potential for ubiquitin pathway enzymes as DDR drug targets for therapeutic intervention. The synthetic lethal approach provides exciting opportunities for the development of targeted therapies to treat cancer: most tumours have lost critical DDR pathways, and thus rely more heavily on the remaining pathways, while normal tissues are still equipped with all DDR pathways. Here, we review key deubiquitylating enzymes (DUBs) involved in DDR pathways, and describe how targeting DUBs may lead to selective therapies to treat cancer patients.
has issue date	2013-05-28(xsd:dateTime)
bibo:doi	10.1007/s12013-013-9635-3
bibo:pmid	23712866
has license	no-cc
sha1sum (hex)	ee46c9064c2ef4916ba7d54c80236d3cb1781635
schema:url	https://doi.org/10.1007/s12013-013-9635-3
resource representing a document's title	Deubiquitylating Enzymes and DNA Damage Response Pathways
has PubMed Central identifier	PMC3756857
has PubMed identifier	23712866
schema:publication	Cell Biochem Biophys
resource representing a document's body	covid:ee46c9064c2ef4916ba7d54c80236d3cb1781635#body_text
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