About: A mathematical design of vector vaccine against autoimmune disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A mathematical design of vector vaccine against autoimmune disease
Creator	Takeuchi, Yasuhiro Iwami, Shingo Iwamoto, Kentaro Naruo, Yoshimi Yasukawa, Masahiro
Source	Elsevier; Medline; PMC
abstract	Abstract Viruses have been implicated in the initiation, progression, and exacerbation of several human autoimmune diseases. Evidence also exists that viruses can protect against autoimmune disease. Several proposed mechanisms explain the viral effects. One mechanism is “molecular mimicry” which represents a shared immunologic epitope with a microbe and the host. We consider, using a simple mathematical model, whether and how a viral infection with molecular mimicry can be beneficial or detrimental for autoimmune disease. Furthermore, we consider the possibility of development of a vector therapeutic vaccine that can relieve autoimmune disease symptoms. Our findings demonstrate that vaccine therapy success necessitates (i) appropriate immune response function, (ii) appropriate affinities with self and non-self antigen, and (iii) a replicative vector vaccine. Moreover, the model shows that the viral infection can cause autoimmune relapses.
has issue date	2009-02-07(xsd:dateTime)
bibo:doi	10.1016/j.jtbi.2008.09.038
bibo:pmid	18996399
has license	els-covid
sha1sum (hex)	f0ea24dbad758b4ef547b8e2c54bd4bb721caf01
schema:url	https://doi.org/10.1016/j.jtbi.2008.09.038
resource representing a document's title	A mathematical design of vector vaccine against autoimmune disease
has PubMed Central identifier	PMC7185877
has PubMed identifier	18996399
schema:publication	Journal of Theoretical Biology
resource representing a document's body	covid:f0ea24dbad758b4ef547b8e2c54bd4bb721caf01#body_text
is schema:about of	named entity 'FINDINGS' named entity 'RELAPSES' named entity 'VIRAL INFECTION' named entity 'AUTOIMMUNE DISEASE' named entity 'AUTOIMMUNE DISEASES' named entity 'POSSIBILITY OF' named entity 'CAUSE' named entity 'MODEL' named entity 'SELF ANTIGEN' named entity 'VECTOR' named entity 'VACCINE THERAPY' named entity 'HAVE' named entity 'MOLECULAR MIMICRY' named entity 'MECHANISM' named entity 'CONSIDER' named entity 'IMMUNE RESPONSE' named entity 'epitope' named entity 'effects' named entity 'autoimmune disease' named entity 'viral infection' named entity 'autoimmune disease' named entity 'SIMPLE' named entity 'THERAPEUTIC VACCINE' covid:arg/f0ea24dbad758b4ef547b8e2c54bd4bb721caf01 named entity 'INITIATION' named entity 'EFFECTS' named entity 'FUNCTION' named entity 'DEVELOPMENT' named entity '28I' named entity 'SHARED' named entity 'EVIDENCE' named entity 'MATHEMATICAL' named entity 'VECTOR VACCINE' named entity 'VIRUSES' named entity 'SELF' named entity 'AUTOIMMUNE' named entity 'AFFINITIES' named entity 'SUCCESS' named entity 'EPITOPE' named entity 'MICROBE' named entity 'MECHANISMS' named entity 'SYMPTOMS' named entity 'AUTOIMMUNE DISEASE' named entity 'DESIGN' named entity 'APPROPRIATE' named entity 'USING' named entity 'HOW' named entity 'VIRAL' named entity 'VECTOR VACCINE' named entity 'PROGRESSION' named entity 'OUR' named entity 'BENEFICIAL' named entity 'HOST' named entity 'NON-SELF' named entity 'RELIEVE' named entity 'MATHEMATICAL MODEL' named entity 'EXACERBATION' named entity 'PROPOSED' named entity 'HUMAN' named entity 'IMMUNOLOGIC' named entity 'MIMICRY' named entity 'therapy' named entity 'vaccine' named entity 'symptoms' named entity 'molecular mimicry' named entity 'function' named entity 'molecular mimicry' named entity 'vaccine therapy' named entity 'vector' named entity 'therapeutic vaccine' named entity 'autoimmune' named entity 'immune response' named entity 'antigen' named entity 'viral infection' named entity 'microbe' named entity 'antigen presenting cells' named entity 'viral infection'

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