About: Methods for sequence and structural analysis of B and T cell receptor repertoires

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Methods for sequence and structural analysis of B and T cell receptor repertoires
Creator	Li, S Xie, J Xu, Z De, M Aybars Nazlica, Sedat Davila, Ana Diez, Diego Ismanto, Hendra Li, Songling Rozewicki, John Saputri, Dianita Standley, Daron Teraguchi, Shunsuke Wilamowski, Jan Xie, Jiaqi Xu, Zichang Anais, M Aybars Nazlica, S Davila, A De, Martin Diez, D Ismanto, H Llamas-Covarrubias, Mara Loza-Lopez, Jesus Nazlica, Aybars Rozewicki, J Saputri, D Standley, D Teraguchi, S Van Eerden, F Van Eerden, Floris Wilamowski, J
topic	covid:f20d70bdc6227dd72cc0fe21855d1b94a18bb447#this
source	Elsevier; Medline; PMC
abstract	B cell receptors (BCRs) and T cell receptors (TCRs) make up an essential network of defense molecules that, collectively, can distinguish self from non-self and facilitate destruction of antigen-bearing cells such as pathogens or tumors. The analysis of BCR and TCR repertoires plays an important role in both basic immunology as well as in biotechnology. Because the repertoires are highly diverse, specialized software methods are needed to extract meaningful information from BCR and TCR sequence data. Here, we review recent developments in bioinformatics tools for analysis of BCR and TCR repertoires, with an emphasis on those that incorporate structural features. After describing the recent sequencing technologies for immune receptor repertoires, we survey structural modeling methods for BCR and TCRs, along with methods for clustering such models. We review downstream analyses, including BCR and TCR epitope prediction, antibody-antigen docking and TCR-peptide-MHC Modeling. We also briefly discuss molecular dynamics in this context.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1016/j.csbj.2020.07.008
bibo:pmid	32802272
has license	no-cc
sha1sum (hex)	f20d70bdc6227dd72cc0fe21855d1b94a18bb447
schema:url	https://doi.org/10.1016/j.csbj.2020.07.008
resource representing a document's title	Methods for sequence and structural analysis of B and T cell receptor repertoires
has PubMed Central identifier	PMC7366105
has PubMed identifier	32802272
schema:publication	Comput Struct Biotechnol J
resource representing a document's body	covid:f20d70bdc6227dd72cc0fe21855d1b94a18bb447#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f20d70bdc6227dd72cc0fe21855d1b94a18bb447
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