About: SARS Antibody Test for Serosurveillance

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS Antibody Test for Serosurveillance
Creator	Hsueh, Po-Ren Kao, Chuan-Liang Lee, Chun-Nan Wang, Chang Ho, Mei-Shang Chen, Li-Kuan Lynn, Shugene Sia, Charles Chang, Yuan Chu, Hsin Dang, Edith Fang, De Guo Xia, Wei Liu, Shi, Kau Tseng, ¶ Walfield, Alan Wang, Jason We, Taiwan Xin, ¶
source	Medline; PMC
abstract	A peptide-based enzyme-linked immunosorbent assay (ELISA) can be used for retrospective serosurveillance of severe acute respiratory syndrome (SARS) by helping identify undetected chains of disease transmission. The assay was developed by epitope mapping, using synthetic peptides from the spike, membrane, and nucleocapsid protein sequences of SARS-associated coronavirus. The new peptide ELISA consistently detected seroconversion by week 2 of onset of fever, and seropositivity remained through day 100. Specificity was 100% on normal blood donor samples, on serum samples associated with infection by other pathogens, and on an interference panel. The peptide-based test has advantages of safety, standardization, and automation over previous immunoassays for SARS. The assay was used for a retrospective survey of healthy healthcare workers in Taiwan who treated SARS patients. Asymptomatic seroconversions were detected in two hospitals that had nosocomial disease.
has issue date	2004-09-01(xsd:dateTime)
bibo:doi	10.3201/eid1009.040101
bibo:pmid	15498156
has license	no-cc
sha1sum (hex)	f2e236f0458f86706985c627ef88d40c8f037492
schema:url	https://doi.org/10.3201/eid1009.040101
resource representing a document's title	SARS Antibody Test for Serosurveillance
has PubMed Central identifier	PMC3320307
has PubMed identifier	15498156
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:f2e236f0458f86706985c627ef88d40c8f037492#body_text
is schema:about of	named entity 'SERUM' named entity 'ANTIBODY TEST' named entity 'SARS' named entity 'SAMPLES' named entity 'CONVALESCENT' named entity 'PROVIDING' named entity 'PATIENTS' named entity 'PHASE' named entity 'SARS' named entity 'CONFIRMED' named entity 'disease transmission' named entity 'nosocomial' named entity 'seroconversion' named entity 'Seroconversion' named entity 'healthcare workers' named entity 'rubella' named entity 'serologic' named entity 'seroconversion' named entity 'peptide' named entity 'SARS-CoV' named entity 'pathogens' named entity 'SARS' named entity 'coronavirus' named entity 'National Taiwan University Hospital' named entity 'pathogens' named entity 'peptide-based' named entity 'Mycoplasma pneumoniae' named entity 'EDTA' named entity 'immunoassays' named entity 'dextrose' named entity 'nosocomial' named entity 'coronavirus' named entity 'molecular epidemiology' named entity 'diagnostic assays' named entity 'SARS' named entity 'Medical Research' named entity 'antibodies' named entity 'Ho Ping' named entity 'SARS' named entity 'virus' named entity 'biosafety level 3' named entity 'infection' named entity 'wild mammals' named entity 'epidemiology' named entity 'peptide-based' named entity 'Center for Disease Control' named entity 'human coronaviruses' named entity 'Absorbance' named entity 'peptides' named entity 'HIV-1' named entity 'recombinant proteins' named entity 'SARS' named entity 'goat' named entity 'China' named entity 'SARS-CoV' named entity 'microbial' named entity 'HIV' named entity 'HIV' named entity 'peptide' named entity 'case definition' named entity 'genomic sequence' named entity 'National Taiwan University Hospital'

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