About: The structural biology of PRRSV

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The structural biology of PRRSV
Creator	Dokland, Terje
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, positive-sense single-stranded RNA virus belonging to the Arteriviridae family. Arteriviruses and coronaviruses are grouped together in the order Nidovirales, based on similarities in genome organization and expression strategy. Over the past decade, crystal structures of several viral proteins, electron microscopic studies of the virion, as well as biochemical and in vivo studies on protein–protein interactions have led to a greatly increased understanding of PRRSV structural biology. At this point, crystal structures are available for the viral proteases NSP1α, NSP1β and NSP4 and the nucleocapsid protein, N. The NSP1α and NSP1β structures have revealed additional non-protease domains that may be involved in modulation of host functions. The N protein forms a dimer with a novel fold so far only seen in PRRSV and other nidoviruses. Cryo-electron tomographic studies have shown the three-dimensional organization of the PRRSV virion and suggest that the viral nucleocapsid has an asymmetric, linear arrangement, rather than the isometric core previously described. Together, these studies have revealed a closer structural relationship between arteri- and coronaviruses than previously anticipated.
has issue date	2010-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2010.07.029
bibo:pmid	20692304
has license	els-covid
sha1sum (hex)	f32df2b12c58f0e31b9a31c92c122b28b7b17aa3
schema:url	https://doi.org/10.1016/j.virusres.2010.07.029
resource representing a document's title	The structural biology of PRRSV
has PubMed Central identifier	PMC7114433
has PubMed identifier	20692304
schema:publication	Virus Research
resource representing a document's body	covid:f32df2b12c58f0e31b9a31c92c122b28b7b17aa3#body_text
is schema:about of	named entity 'led' named entity 'closer' named entity 'core' named entity 'STUDIES' named entity 'DECADE' named entity 'STRUCTURAL' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'IN VIVO STUDIES' named entity 'CORONAVIRUSES' named entity 'INVOLVED' named entity 'DESCRIBED' named entity 'UNDERSTANDING' named entity 'PROTEASE' named entity 'NOVEL' named entity 'POSITIVE' named entity 'NSP4' named entity 'RELATIONSHIP' named entity 'HAVE' named entity 'BASED' named entity 'ANTICIPATED' named entity 'ISOMETRIC' named entity 'ORDER NIDOVIRALES' named entity 'ELECTRON' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'STRUCTURAL BIOLOGY' named entity 'PRRSV' named entity 'CRYSTAL' named entity 'FOLD' named entity '90%' named entity 'ARTERI' named entity 'BELONGING' named entity 'RNA VIRUS' named entity 'MICROSCOPIC' named entity 'ASYMMETRIC' named entity 'DIMER' named entity 'REVEALED' named entity 'SEEN' named entity 'NON-' named entity 'BIOCHEMICAL' named entity 'CORE' named entity 'EXPRESSION' named entity 'VIRAL NUCLEOCAPSID' named entity 'HOST' named entity 'THREE-DIMENSIONAL' named entity 'PROTEASES' named entity 'INCREASED' named entity 'POINT' named entity 'VIRION' named entity 'FAR' named entity 'AVAILABLE' named entity 'THESE' named entity 'STRUCTURES' named entity 'PREVIOUSLY' named entity 'NUCLEOCAPSID PROTEIN' named entity 'FAMILY' named entity 'GENOME ORGANIZATION' named entity 'PAST' named entity 'STRUCTURAL BIOLOGY' named entity 'NSP1' named entity 'FORMS' named entity 'LED' named entity 'FUNCTIONS' named entity 'VIRAL PROTEINS' named entity 'STRATEGY' named entity 'ARTERIVIRIDAE' named entity 'ARRANGEMENT' named entity 'ADDITIONAL' named entity 'VIRAL' named entity 'PROTEIN ' named entity 'N PROTEIN' named entity 'SENSE' named entity 'GREATLY' named entity 'ORGANIZATION' named entity 'ARTERIVIRUSES' named entity 'MAY BE' named entity 'MODULATION' named entity 'GROUPED' named entity 'RATHER' named entity 'LINEAR' named entity 'SUGGEST' covid:arg/f32df2b12c58f0e31b9a31c92c122b28b7b17aa3

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