About: Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study
Creator	Guo, Yan Huang, Wei Chen, Hao Zhang, Zhang, Kun Ding, Jing-Miao Dong, Shan-Shan Wang, Zhuo-Xin Yang, Tie-Lin Yao, Shi Zhu, Dong-Li
Source	MedRxiv
abstract	Background: Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). It has been found that coronary artery disease (CAD) is a comorbid condition for COVID-19. As the risk factors of CAD, whether blood lipids levels are causally related to increasing susceptibility and severity of COVID-19 is still unknown. Design: We performed two-sample Mendelian Randomization (MR) analyses to explore whether dyslipidemia, low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), triglyceride (TG) and total cholesterol (TC) were causally related to COVID-19 risk and severity. The GWAS summary data of blood lipids involving in 188,578 individuals and dyslipidemia in a total of 53,991 individuals were used as exposures, respectively. Two COVID-19 GWASs including 1,221 infected patients and 1,610 severe patients defined as respiratory failure were employed as outcomes. Based on the MR estimates, we further carried out gene-based and gene-set analysis to explain the potential mechanism for causal effect. Results: The MR results showed that dyslipidemia was casually associated with the susceptibility of COVID-19 and induced 27% higher odds for COVID-19 infection (MR-IVW OR = 1.27, 95% CI: 1.08 to 1.49, p-value = 3.18 x 10-3). Moreover, the increasing level of blood TC will raise 14 % higher odds for the susceptibility of COVID-19 (MR-IVW OR = 1.14, 95% CI: 1.04 to 1.25, p-value = 5.07 x 10-3). Gene-based analysis identified that ABO gene was associated with TC and the gene-set analysis found that immune processes were involved in the risk effect of TC. Conclusions: We obtained three conclusions: 1) Dyslipidemia is casually associated with the susceptibility of COVID-19; 2) TC is a risk factor for the susceptibility of COVID-19; 3) The different susceptibility of COVID-19 in specific blood group may be partly explained by the TC concentration in diverse ABO blood groups.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.1101/2020.07.07.20147926
has license	medrxiv
sha1sum (hex)	f37cbfd2aed8d693e2e9440079f5602148a6cd66
schema:url	https://doi.org/10.1101/2020.07.07.20147926
resource representing a document's title	Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study
resource representing a document's body	covid:f37cbfd2aed8d693e2e9440079f5602148a6cd66#body_text
is schema:about of	named entity 'levels' named entity 'CAD' named entity 'dyslipidemia' named entity 'density' named entity 'dyslipidemia' named entity 'Mendelian Randomization' named entity 'respiratory' named entity 'cholesterol' named entity 'risk' named entity 'COVID-19' named entity 'respiratory failure' named entity 'explore' named entity 'blood lipids' named entity 'individuals' named entity 'GWAS' named entity 'performed' named entity 'dyslipidemia' named entity 'coronary artery disease' named entity 'cholesterol' named entity 'COVID-19' named entity 'coronavirus 2' named entity 'Mendelian' named entity 'respiratory failure' named entity 'SARS-Cov-2' named entity 'Mendelian' named entity 'data' named entity 'dyslipidemia' named entity 'COVID-19' named entity 'blood group' named entity 'preprint' named entity 'COVID-19' named entity 'July 7' named entity 'preprint' named entity 'causally related' named entity 'preprint' named entity 'blood group' named entity 'ABO gene' named entity 'cholesterol' named entity 'pleiotropy' named entity 'CC-BY-NC-ND 4.0' named entity 'peer review' named entity 'IVW' named entity 'preprint' named entity 'SNP' named entity 'pleiotropy' named entity 'preprint' named entity 'medRxiv' named entity 'blood group' named entity 'gene' named entity 'COVID-19' named entity 'CC-BY-NC-ND 4.0' named entity 'gene' named entity 'COVID-19' named entity 'gene' named entity 'medRxiv' named entity 'COVID-19' named entity 'hg19' named entity 'preprint' named entity 'blood lipids' named entity 'antigen' named entity 'allele' named entity 'CC-BY-NC-ND 4.0' named entity 'gene' named entity 'medRxiv' named entity 'dyslipidemia' named entity 'causal effects' named entity 'blood group' named entity 'gene' named entity 'CC-BY-NC-ND 4.0' named entity 'medRxiv' named entity 'COVID-19' named entity 'ABO blood group' named entity 'CC-BY-NC-ND 4.0' named entity 'gene' named entity 'blood group'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software