About: Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells

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About: Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells
Creator	Okabayashi, Tamaki Kubo, Meiko Mekata, Hirohisa Saito, Akatsuki Sudaryatma, Putu Fahkrajang, Watcharapong Sudaryatma, Eka
Source	Elsevier; Medline; PMC
abstract	The synergistic infection of bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) may predispose cattle to develop severe pneumonia. Previously, we reported that BRSV infection significantly decreased PM adherence to the upper respiratory epithelial cells. It may allow bacteria to invade into the lower respiratory tract and lead to severe pneumonia. To investigate whether BRSV infection regulates the cell surface adherence receptor on bovine trachea epithelial cells (bTECs), we performed proteomic and functional analyses. BRSV infection decreased the expression of intercellular adhesion molecule-1 (ICAM1) on bTECs. Inhibition and knockdown experiments using anti-ICAM1 antibody and siRNAs targeting ICAM1 indicated that PM adherence to bTECs was dependent on ICAM1 expression. These data suggest that under normal conditions bTECs may capture PM in the upper respiratory tract, while BRSV infection reverses this mechanism. The proposed gateway function of bTECs is disrupted by BRSV infection that may facilitate bacterial invasion into the lower respiratory tract and lead to secondary or more severe respiratory infection.
has issue date	2020-06-02(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2020.108748
bibo:pmid	32605748
has license	no-cc
sha1sum (hex)	f3d2304e806aaecfbea3867c6d9cc78802950a27
schema:url	https://doi.org/10.1016/j.vetmic.2020.108748
resource representing a document's title	Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells
has PubMed Central identifier	PMC7265823
has PubMed identifier	32605748
schema:publication	Vet Microbiol
resource representing a document's body	covid:f3d2304e806aaecfbea3867c6d9cc78802950a27#body_text
is schema:about of	named entity 'ICAM1' named entity 'severe' named entity 'bTECs' named entity 'analyses' named entity 'respiratory tract' named entity 'data' named entity 'Respiratory' named entity 'Bovine' named entity 'THESE' named entity 'INHIBITION' named entity 'FUNCTION' named entity 'CATTLE' named entity 'TRACHEA' named entity 'INTERACTION' named entity 'DISRUPTED' named entity 'Pasteurella' named entity 'respiratory' named entity 'adherence' named entity 'pneumonia' named entity 'pneumonia' named entity 'infection' named entity 'ICAM1' named entity 'predispose' named entity 'cattle' named entity 'upper' named entity 'regulated' named entity 'siRNAs' named entity 'P. multocida' named entity 'Inhibition' named entity 'intercellular adhesion molecule-1' named entity 'Pasteurella' named entity 'Adhesion' named entity 'epithelial cells' named entity 'severe pneumonia' named entity 'bTECs' named entity 'bTECs' named entity 'upper respiratory tract' named entity 'bacteria' named entity 'P. multocida' named entity 'bTECs' named entity 'infection' named entity 'bovine' named entity 'intercellular adhesion molecule-1' named entity 'lower respiratory tract' named entity 'Upper respiratory tract' named entity 'lower respiratory tract' named entity 'Respiratory Syncytial Virus' named entity 'Bovine' named entity 'Epithelial Cells' named entity 'Respiratory Syncytial Virus' named entity 'bTECs' named entity 'ICAM1' named entity 'viruses' named entity 'ICAM1' named entity 'lower respiratory tract' named entity 'ICAM1' named entity 'mRNA' named entity 'epidermal growth factor' named entity 'Thermo Fisher Scientific' named entity 'organ' named entity 'ICAM1' named entity 'JSPS' named entity 'statistically significant' named entity 'bTECs' named entity 'MOI' named entity 'negative-stranded RNA virus' named entity 'bTECs' named entity 'epithelial cells' named entity 'Dulbecco's modified Eagle's medium' named entity 'epithelial cells' named entity 'viruses' named entity 'dose-dependent manner' named entity 'cell surface receptors' named entity 'rhinovirus' named entity 'Tissues'

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