About: Digesting Oneself and Digesting Microbes: Autophagy as a Host Response to Viral Infection

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About: Digesting Oneself and Digesting Microbes: Autophagy as a Host Response to Viral Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Digesting Oneself and Digesting Microbes: Autophagy as a Host Response to Viral Infection
Creator	Levine, Beth Dinesh-Kumar, Savithramma Seay, Montrell
Source	PMC
abstract	Although research in this area is still in a stage of infancy, it seems likely that the lysosomal degradation pathway of autophagy plays an evolutionarily conserved role in antiviral immunity. The interferon-inducible, antiviral PKR signaling pathway positively regulates autophagy, and both mammalian and plant autophagy genes restrict viral replication and protect against virus-induced cell death. Given this role of autophagy in innate immunity, it is not surprising that viruses have evolved numerous strategies to inhibit host autophagy. Different viral gene products can either modulate autophagy regulatory signals or directly interact with components of the autophagy execution machinery. Moreover, certain RNA viruses have managed to “co-apt” the autophagy pathway, selectively utilizing certain components of the dynamic membrane rearrangement system to promote their own replication inside the host cytoplasm. In addition to this newly emerging role of autophagy in innate immunity, autophagy plays an important role in many other fundamental biological processes, including tissue homeostasis, differentiation and development, cell growth control, and the prevention of aging. Accordingly, the inhibition of host autophagy by viral gene products has important implications not only for understanding mechanisms of immune evasion, but also for understanding novel mechanisms of viral pathogenesis. It will be interesting to dissect the role of viral inhibition of autophagy in acute, persistent, and latent viral replication, as well as in the pathogenesis of cancer and other medical diseases.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/1-4020-3242-0_11
has license	no-cc
sha1sum (hex)	f3f1b9125bf09248d0d557710062aedde654113b
schema:url	https://doi.org/10.1007/1-4020-3242-0_11
resource representing a document's title	Digesting Oneself and Digesting Microbes: Autophagy as a Host Response to Viral Infection
has PubMed Central identifier	PMC7121853
schema:publication	Modulation of Host Gene Expression and Innate Immunity by Viruses
resource representing a document's body	covid:f3f1b9125bf09248d0d557710062aedde654113b#body_text
is schema:about of	named entity 'retrovirus' named entity 'long-lived' named entity 'ER stress' named entity 'cell growth' named entity 'EBV' named entity 'autophagosomes' named entity 'autophagy' named entity 'endogenous' named entity 'avirulence' named entity 'viruses' named entity 'yeast two-hybrid screen' named entity 'Gcn2' named entity 'antibody' named entity 'signaling molecules' named entity 'autophagy' named entity 'virus infection' named entity 'phosphorylation' named entity 'atg' named entity 'C. elegans' named entity 'nutrient' named entity 'yeast' named entity 'HSV-1' named entity 'Huntington's disease' named entity 'eukaryotes' named entity 'autophagy' named entity 'neurons' named entity 'autophagy' named entity 'autophagy' named entity 'viruses' named entity 'mouse model' named entity 'oncoproteins' named entity 'autophagic' named entity 'intracellular' named entity 'protein' named entity 'PKR' named entity 'Beclin 1' named entity 'conjugation' named entity 'negative regulator' named entity 'wild-type' named entity 'kinase' named entity 'nutrient recycling' named entity 'tissue homeostasis' named entity 'organelles' named entity 'recycle nutrients' named entity 'infection' named entity 'nucleotide' named entity 'Atg1' named entity 'autophagy' named entity 'PKR' named entity 'PI3-K/Akt' named entity 'pathogenetic' named entity 'pathogenesis' named entity 'dynamic process' named entity 'autophagosomes' named entity 'Sindbis' named entity 'autophagy' named entity 'organism' named entity 'PI3-K' named entity 'eIF2' named entity 'autophagy' named entity 'Atg1' named entity 'binding domain' named entity 'infection' named entity 'autophagy' named entity 'viruses' named entity 'herpes simplex virus' named entity 'pro-death' named entity 'yeast' named entity 'viruses' named entity 'autophagy' named entity 'protein' named entity 'atg7' named entity 'HSV-1' named entity 'ICP34.5' named entity 'Beclin 1' named entity 'autophagy' named entity 'cell death' named entity 'autophagic' named entity 'eIF2' named entity 'autophagy' named entity 'starvation'

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