About: NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused by Schistosoma mansoni Infection

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About: NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused by Schistosoma mansoni Infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused by Schistosoma mansoni Infection
Creator	Jones, Malcolm Oliveira, Sergio Xu, Hsieh, Michael Guimarães, Erika Mambelli, Fábio Marinho, Fabio Morais, Suellen Sanches, Rodrigo Souza, Cláudia Australia, Zhipeng
Source	PMC
abstract	Schistosomiasis is a debilitating parasitic disease that affects more than 200 million people worldwide and causes approximately 280,000 deaths per year. Inside the definitive host, eggs released by Schistosoma mansoni lodge in the intestine and especially in the liver where they induce a granulomatous inflammatory process, which can lead to fibrosis. The molecular mechanisms initiating or promoting hepatic granuloma formation remain poorly understood. Inflammasome activation has been described as an important pathway to induce pathology mediated by NLRP3 receptor. Recently, other components of the inflammasome pathway, such as NLRP6, have been related to liver diseases and fibrotic processes. Nevertheless, the contribution of these components in schistosomiasis-associated pathology is still unknown. In the present study, using dendritic cells, we demonstrated that NLRP6 sensor is important for IL-1β production and caspase-1 activation in response to soluble egg antigens (SEA). Furthermore, the lack of NLRP6 has been shown to significantly reduce periovular inflammation, collagen deposition in hepatic granulomas and mRNA levels of α-SMA and IL-13. Livers of Nlrp6(–/–) mice showed reduced levels of CXCL1/KC, CCL2, CCL3, IL-5, and IL-10 as well as Myeloperoxidase (MPO) and Eosinophilic Peroxidase (EPO) enzymatic activity. Consistently, the frequency of macrophage and neutrophil populations were lower in the liver of NLRP6 knockout mice, after 6 weeks of infection. Finally, it was further demonstrated that the onset of hepatic granuloma and collagen deposition were also compromised in Caspase-1(–/–), IL-1R(–/–) and Gsdmd(–/–) mice. Our findings suggest that the NLRP6 inflammasome is an important component for schistosomiasis-associated pathology.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.00795
bibo:pmid	32431709
has license	cc-by
sha1sum (hex)	f4b6e6bb1d5a8ae6612c2ba25448aaa48058ad14
schema:url	https://doi.org/10.3389/fimmu.2020.00795
resource representing a document's title	NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused by Schistosoma mansoni Infection
has PubMed Central identifier	PMC7214731
has PubMed identifier	32431709
schema:publication	Front Immunol
resource representing a document's body	covid:f4b6e6bb1d5a8ae6612c2ba25448aaa48058ad14#body_text
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