About: Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients

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About: Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients
Creator	Detrick, Barbara Gangaputra, Sapna Heaney, Christopher Hooks, John Palsgrove, Doreen Sen, H
Source	Elsevier; Medline; PMC
abstract	Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated retinopathy associated with circulating antiretinal antibodies (ARAs). Other prominent features of AIR include visual field deficits and photoreceptor dysfunction in the setting of progressive unexplained vision loss. The role of inflammation is poorly understood in AIR. Since cytokines play a central role in the initiation and development of inflammation, we evaluated the presence of proinflammatory cytokines and chemokines in AIR patient sera. We demonstrate that IL-6 and CXCL9 are both elevated in AIR patient sera. Moreover, the presence and concentration of these 2 molecules appear to correlate with AIR patient disease severity. This cytokine profile, IL-6 and CXCL9, has been described to participate in a variety of autoimmune and inflammatory diseases. Our study provides support for an activated inflammatory process in AIR and identifies possible mechanisms that can drive autoimmunity in this disease.
has issue date	2018-03-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2017.12.014
bibo:pmid	29310941
has license	els-covid
sha1sum (hex)	f61e882d447ad3f4eee81d8242869dc201042d89
schema:url	https://doi.org/10.1016/j.jneuroim.2017.12.014
resource representing a document's title	Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients
has PubMed Central identifier	PMC5801042
has PubMed identifier	29310941
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:f61e882d447ad3f4eee81d8242869dc201042d89#body_text
is schema:about of	named entity 'mechanisms' named entity 'AIR' named entity 'initiation' named entity 'central' named entity 'ELEVATED' named entity 'APPEAR' named entity 'PRESENCE' named entity 'CXCL9' named entity 'DEVELOPMENT' named entity 'ACTIVATED' named entity 'VISUAL FIELD' named entity 'ANTIRETINAL ANTIBODIES' named entity 'DESCRIBED' named entity 'ASSOCIATED WITH' named entity 'UNEXPLAINED' named entity 'PROGRESSIVE' named entity 'POSSIBLE' named entity 'INFLAMMATION' named entity 'SERUM' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'PROMINENT' named entity 'RARE' named entity 'THESE' named entity 'CONCENTRATION OF' named entity 'MECHANISMS' named entity 'PHOTORECEPTOR' named entity 'EVALUATED' named entity 'PROVIDES' named entity 'AUTOIMMUNE' named entity 'CHEMOKINES' named entity 'CYTOKINES' named entity 'ROLE' named entity 'IS A' named entity 'AIR' named entity 'INFLAMMATORY DISEASES' named entity 'SUPPORT' named entity 'SERA' named entity 'DISEASE SEVERITY' named entity 'ELEVATED' covid:arg/f61e882d447ad3f4eee81d8242869dc201042d89 named entity 'VARIETY' named entity 'CENTRAL' named entity 'CIRCULATING' named entity 'TO PARTICIPATE' named entity 'IL-6' named entity 'LEVELS' named entity 'AUTOIMMUNE RETINOPATHY' named entity 'PATIENTS' named entity 'CXCL9' named entity 'RETINOPATHY' named entity 'MOLECULES' named entity 'AUTOIMMUNE RETINOPATHY' named entity 'INFLAMMATORY PROCESS' named entity 'INCLUDE' named entity 'UNDERSTOOD' named entity 'STUDY' named entity 'DRIVE' named entity 'INITIATION' named entity 'AUTOIMMUNITY' named entity 'IMMUNE-MEDIATED' named entity 'DEFICITS' named entity 'FEATURES' named entity 'PRESENCE OF' named entity 'VISION LOSS' named entity 'CYTOKINE PROFILE' named entity 'DYSFUNCTION' named entity 'DISEASE' named entity 'POORLY' named entity 'IL-6' named entity 'SETTING' named entity 'OUR' named entity 'PLAY' named entity 'PATIENT' named entity 'demonstrate' named entity 'identifies' named entity 'study'

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