About: SGTA: A New Player in the Molecular Co-Chaperone Game

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SGTA: A New Player in the Molecular Co-Chaperone Game
Creator	Butler, Lisa Butler, Miriam Day, Tanya Hickey, Theresa Philp, Lisa Tilley, Wayne
source	Medline; PMC
abstract	Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) is a steroid receptor molecular co-chaperone that may substantially influence hormone action and, consequently, hormone-mediated carcinogenesis. To date, published studies describe SGTA as a protein that is potentially critical in a range of biological processes, including viral infection, cell division, mitosis, and cell cycle checkpoint activation. SGTA interacts with the molecular chaperones, heat shock protein 70 (HSP70) and HSP90, and with steroid receptor complexes, including those containing the androgen receptor. Steroid receptors are critical for maintaining cell growth and differentiation in hormonally regulated tissues, such as male and female reproductive tissues, and also play a role in disease states involving these tissues. There is growing evidence that, through its interactions with chaperones and steroid receptors, SGTA may be a key player in the pathogenesis of hormonally influenced disease states, including prostate cancer and polycystic ovary syndrome. Research into the function of SGTA has been conducted in several model organisms and cell types, with these studies showing that SGTA functionality is cell-specific and tissue-specific. However, very few studies have been replicated in multiple cell types or experimental systems. Although a broad range of functions have been attributed to SGTA, there is a serious lack of mechanistic information to describe how SGTA acts. In this review, published evidence linking SGTA with hormonally regulated disease states is summarized and discussed, highlighting the need for future research to more clearly define the biological function(s) of this potentially important co-chaperone. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12672-013-0151-0) contains supplementary material, which is available to authorized users.
has issue date	2013-07-02(xsd:dateTime)
bibo:doi	10.1007/s12672-013-0151-0
bibo:pmid	23818240
has license	no-cc
sha1sum (hex)	f6d81903bcffba15f2dc44fc7e61ccde1b4ac4cd
schema:url	https://doi.org/10.1007/s12672-013-0151-0
resource representing a document's title	SGTA: A New Player in the Molecular Co-Chaperone Game
has PubMed Central identifier	PMC7091355
has PubMed identifier	23818240
schema:publication	Horm Cancer
resource representing a document's body	covid:f6d81903bcffba15f2dc44fc7e61ccde1b4ac4cd#body_text
is schema:about of	named entity 'CO-CHAPERONE' named entity 'studies' named entity 'functionality' named entity 'molecular' named entity 'Although' named entity 'studies' named entity 'Research' named entity 'cell types' named entity 'NEW' named entity 'MULTIPLE' named entity 'INVOLVING' named entity 'PUBLISHED' named entity 'IMPORTANT' named entity 'ANDROGEN RECEPTOR' named entity 'MAY BE A' named entity 'BIOLOGICAL FUNCTION' named entity 'LACK' named entity 'A PROTEIN' named entity 'EXPERIMENTAL' named entity 'MOLECULAR CHAPERONES' named entity 'CONTAINING' named entity 'ACTION' named entity 'ROLE' named entity 'A STEROID' named entity 'MAINTAINING' named entity 'DIFFERENTIATION' named entity 'RICH' named entity 'RESEARCH' named entity 'SMALL' named entity 'CARCINOGENESIS' named entity 'LINKING' named entity 'COMPLEXES' named entity 'FUNCTIONALITY' named entity 'INTERACTIONS' named entity 'STUDIES' named entity 'INCLUDING' named entity 'RANGE' named entity 'STEROID' named entity 'PATHOGENESIS' named entity 'MITOSIS' named entity 'CELL GROWTH' named entity 'NEED FOR' named entity 'GAME' named entity 'ACTIVATION' named entity 'REVIEW' named entity 'REPRODUCTIVE' named entity 'HEAT SHOCK PROTEIN 70' named entity 'BROAD' named entity 'DESCRIBE' named entity 'VIRAL INFECTION' named entity 'SPECIFIC' named entity 'SYSTEMS' named entity 'MEDIATED' named entity 'FUNCTIONS' named entity 'EVIDENCE' named entity 'TISSUES' named entity 'KEY' named entity 'BIOLOGICAL PROCESSES' named entity 'STEROID RECEPTOR' named entity 'HIGHLIGHTING' named entity 'SGTA' named entity '28S' named entity 'PLAY' named entity 'IS A' named entity '2C CELL' named entity 'RECEPTORS' named entity 'MOLECULAR' named entity 'DISEASE' named entity 'REPLICATED' named entity 'CELL TYPES' named entity 'SGTA' named entity 'ITS' named entity 'HSP90' named entity 'PROSTATE CANCER' named entity 'TO DESCRIBE' named entity 'HORMONE'

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