About: Global importance of RNA secondary structures in protein-coding sequences

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Global importance of RNA secondary structures in protein-coding sequences
Creator	Marz, Manja Fricke, Markus Ibrahim, Bashar Gerst, Ruman Niepmann, Michael
source	PMC
abstract	MOTIVATION: The protein-coding sequences of messenger RNAs are the linear template for translation of the gene sequence into protein. Nevertheless, the RNA can also form secondary structures by intramolecular base-pairing. RESULTS: We show that the nucleotide distribution within codons is biased in all taxa of life on a global scale. Thereby, RNA secondary structures that require base-pairing between the position 1 of a codon with the position 1 of an opposing codon (here named RNA secondary structure class c(1)) are under-represented. We conclude that this bias may result from the co-evolution of codon sequence and mRNA secondary structure, suggesting that RNA secondary structures are generally important in protein-coding regions of mRNAs. The above result also implies that codon position 2 has a smaller influence on the amino acid choice than codon position 1. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.1093/bioinformatics/bty678
bibo:pmid	30101307
has license	no-cc
sha1sum (hex)	f709e1a7aa2a4bdec107bd32cb72963c0b224ee3
schema:url	https://doi.org/10.1093/bioinformatics/bty678
resource representing a document's title	Global importance of RNA secondary structures in protein-coding sequences
has PubMed Central identifier	PMC7109657
has PubMed identifier	30101307
schema:publication	Bioinformatics
resource representing a document's body	covid:f709e1a7aa2a4bdec107bd32cb72963c0b224ee3#body_text
is schema:about of	named entity 'NUCLEOTIDE' named entity 'RNA' named entity 'INFLUENCE' named entity 'CHOICE' named entity 'AMINO ACID' named entity 'LINEAR' named entity 'MESSENGER' named entity 'CONCLUDE' named entity 'RESULTS' named entity 'PROTEIN-CODING' named entity 'BIAS' named entity 'RNA' named entity 'CODON SEQUENCE' named entity 'REGIONS' named entity 'BIASED' named entity 'DISTRIBUTION' named entity 'SEQUENCES' named entity 'RNAS' named entity 'GLOBAL' named entity 'TEMPLATE' named entity 'CODON' named entity 'PROTEIN-CODING' named entity 'CO-EVOLUTION' named entity 'GENERALLY' named entity 'SEQUENCES' named entity 'STRUCTURES' named entity 'SECONDARY' named entity 'BASE-PAIRING' named entity 'FORM' named entity 'STRUCTURES' named entity 'MRNA' named entity 'NAMED' named entity 'POSITION' named entity 'TRANSLATION' named entity 'RNA SECONDARY STRUCTURE' named entity 'SECONDARY STRUCTURE' named entity 'IMPORTANT' named entity 'SMALLER' named entity 'PROTEIN' named entity 'CODONS' named entity 'RESULT' named entity 'CLASS C' named entity 'SECONDARY' named entity 'GLOBAL SCALE' named entity 'TAXA' named entity 'LIFE' named entity 'codon' named entity 'protein' named entity 'codon' named entity 'mRNAs' named entity 'RNA secondary structures' named entity 'position 1' named entity 'nucleotide' named entity 'taxa' named entity 'amino acid' named entity 'RNA secondary structures' named entity 'amino acids' named entity 'taxa' named entity 'codons' named entity 'coding regions' named entity 'codons' named entity 'viruses' named entity 'codon' named entity 'secondary structure prediction' named entity 'ribosomes' named entity 'codons' named entity 'plastid' named entity 'hydrophobic' named entity 'plastid' named entity 'RefSeq' named entity 'chloroplast' named entity 'ribosomes' named entity 'codon' named entity 'codon' named entity 'selection pressure' named entity 'protein-coding regions' named entity 'genomes'

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