About: MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity

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About: MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity
Creator	Peiris, Malik Zhao, Jincun Drosten, Christian Rambaut, Andrew Munster, Vincent Perlman, Stanley Poon, Leo Muth, Doreen Miguel, Eve Chevalier, Veronique Ali, Abraham Zhou, Ziqi Channappanavar, Rudragouda Dudas, Gytis Niemeyer, Daniela Roger, Francois Fassi-Fihri, Ouafaa Mamo, Gezahegne Traoré, Amadou Chu, Daniel Webby, Richard Meyerholz, David Nicholls, John Chan, Michael Hemida, Maged Hui, Kenrie Morse, Stephen Perera, Ranawaka Demissié, Getnet Oladipo, Jamiu So, Ray Kuranga, Sulyman
topic	covid:f77d9d6d6d7730a6a554319266051a8b1e36970b#this
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene ORF4b. Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking ORF4b elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, ORF4b deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal–human interface.
has issue date	2018-03-20(xsd:dateTime)
bibo:doi	10.1073/pnas.1718769115
bibo:pmid	29507189
has license	cc-by-nc-nd
sha1sum (hex)	f77d9d6d6d7730a6a554319266051a8b1e36970b
schema:url	https://doi.org/10.1073/pnas.1718769115
resource representing a document's title	MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity
has PubMed Central identifier	PMC5866576
has PubMed identifier	29507189
schema:publication	Proc Natl Acad Sci U S A
resource representing a document's body	covid:f77d9d6d6d7730a6a554319266051a8b1e36970b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f77d9d6d6d7730a6a554319266051a8b1e36970b
is schema:about of	named entity 'CREATIVE COMMONS' named entity 'PAPER' named entity 'NC-' named entity 'WROTE' named entity 'S.M' named entity 'ACCESS' named entity 'ARTICLE' named entity 'Health' named entity 'OPEN' named entity 'EXHIBIT' named entity 'REGION' named entity 'NATIONAL INSTITUTES OF HEALTH' named entity 'AFRICA' named entity 'DEPENDENT' named entity 'GENETIC DIVERSITY' named entity 'CAMELS' named entity 'MERS' named entity 'ANALYZED' named entity 'COLUMBIA UNIVERSITY' named entity 'AUTHORS' named entity 'RESEARCH' named entity 'ATTRIBUTION' named entity 'DATA' named entity 'DISTRIBUTED' named entity 'CORONAVIRUSES' named entity 'NEW' named entity 'REAGENTS' named entity 'CONFLICT OF INTEREST' named entity 'TOOLS' named entity 'LICENSE' named entity 'M.P.' named entity 'authors' named entity 'tools' named entity 'coronaviruses' named entity 'Columbia University' named entity 'A.R' named entity 'Africa' named entity 'genetic diversity' named entity 'MERS-CoV' named entity 'phenotypically' named entity 'clade' named entity 'Erasmus University Medical Center' named entity 'serum' named entity 'deletions' named entity 'viruses' named entity 'phenotypic' named entity 'MERS-CoV' named entity 'clone'

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