About: Ultrastructural Characterization of Zika Virus Replication Factories

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ultrastructural Characterization of Zika Virus Replication Factories
Creator	Bartenschlager, Ralf Chatel-Chaix, Laurent Cortese, Mirko Ruggieri, Alessia Schieber, Nicole Schwab, Yannick Funaya, Charlotta Goellner, Sarah Haselmann, Uta Lampe, Marko Oleksiuk, Olga Pruunsild, Priit Ronchi, Paolo Schorb, Martin Acosta, Eliana Neufeldt, Christopher
Source	Elsevier; Medline; PMC
abstract	A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs). Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organelles. Analyses of human hepatic cells and neural progenitor cells infected with ZIKV revealed endoplasmic reticulum (ER) membrane invaginations containing pore-like openings toward the cytosol, reminiscent to RFs in Dengue virus-infected cells. Both the MR766 African strain and the H/PF/2013 Asian strain, the latter linked to neurological diseases, induce RFs of similar architecture. Importantly, ZIKV infection causes a drastic reorganization of microtubules and intermediate filaments forming cage-like structures surrounding the viral RF. Consistently, ZIKV replication is suppressed by cytoskeleton-targeting drugs. Thus, ZIKV RFs are tightly linked to rearrangements of the host cell cytoskeleton.
has issue date	2017-02-28(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2017.02.014
bibo:pmid	28249158
has license	cc-by
sha1sum (hex)	f78f42cdcf23e60059e6ef785c1d72072824832a
schema:url	https://doi.org/10.1016/j.celrep.2017.02.014
resource representing a document's title	Ultrastructural Characterization of Zika Virus Replication Factories
has PubMed Central identifier	PMC5340982
has PubMed identifier	28249158
schema:publication	Cell Rep
resource representing a document's body	covid:f78f42cdcf23e60059e6ef785c1d72072824832a#body_text
is schema:about of	named entity 'Replication' named entity 'VIRUS REPLICATION' named entity 'ZIKA VIRUS' named entity 'CHARACTERIZATION' named entity 'FACTORIES' named entity 'INFORMATION' named entity 'SUPPLEMENTAL' named entity 'inoculated' named entity 'vesicle' named entity 'metadata' named entity 'GFP' named entity 'DMSO' named entity 'Ultrastructural' named entity 'Zika Virus' named entity 'Life Technologies' named entity 'IgG1' named entity 'Bio-Rad' named entity 'Incubation' named entity 'FGF2' named entity 'DAPI' named entity 'pore size' named entity 'infection' named entity 'infection' named entity 'virus' named entity 'refractive index' named entity 'PBS' named entity 'intracellular' named entity 'invaginated' named entity 'ethanol' named entity 'GFP' named entity 'DMSO' named entity 'cDNA' named entity 'FIB-SEM' named entity 'paclitaxel' named entity 'Fiji' named entity 'FIB-SEM' named entity 'crystal violet' named entity 'Applied Biosystems' named entity 'EDTA' named entity 'inoculated' named entity 'centrifugation' named entity 'glycine' named entity 'methanol' named entity 'infection' named entity 'PerkinElmer' named entity 'EGTA' named entity 'EMD Millipore' named entity 'far-red' named entity 'cDNA' named entity 'EGF' named entity 'immunostaining' named entity 'tubulin' named entity 'Supernatants' named entity '1:500' named entity 'GFP' named entity 'Huh7' named entity 'staining' named entity 'RT-qPCR' named entity 'SEM' named entity 'supernatants' named entity 'TEM' named entity 'FIB-SEM' named entity 'fixative' named entity 'glutaraldehyde' named entity 'DMSO' named entity 'DMEM'

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