About: Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1
Creator	Jones, Clinton Perez, Sandra Henderson, Gail Jiang, Yunquan Meyer, Florencia Zhou, You
Source	Medline; PMC
abstract	The latency-related (LR) RNA encoded by bovine herpesvirus 1 (BHV-1) is abundantly expressed and alternatively spliced in trigeminal ganglia. A mutant BHV-1 strain that contains three stop codons at the beginning of LR open reading frame (ORF)-2 (LR mutant virus) does not express ORF-2 or an adjacent reading frame that lacks an initiating ATG (RF-C). Calves latently infected with wild-type (wt) BHV-1, but not with the LR mutant virus, reactivate from latency, indicating that proteins encoded by the LR gene regulate the latency-reactivation cycle. The LR gene also contains another large ORF (ORF-1) that is approximately 200 bp downstream of stop codons inserted at the N-terminus of ORF-2. To test whether the LR mutant virus can expresses ORF-1, the authors developed antiserum directed against ORF-1. The ORF-1 antiserum recognizes specific proteins in bovine cells productively infected with wt BHV-1. ORF-1 protein expression is reduced, but not blocked, when bovine cells are infected with the LR mutant virus. Confocal microscopy demonstrated ORF-1 is present in the cytoplasm and nucleus of productively infected cells, whereas RF-C or a fusion protein containing RF-C localizes to the cytoplasm. Trigeminal ganglia from calves latently infected with wt BHV-1 contain neurons specifically stained with the ORF-1 antiserum. These studies suggest ORF-1 expression may be important for the BHV-1 latency-reactivation cycle.
has issue date	2007-01-01(xsd:dateTime)
bibo:doi	10.1080/13550280701620754
bibo:pmid	18097888
has license	no-cc
sha1sum (hex)	f7da12cb128e48642765cfa54c58920d5bce89c4
schema:url	https://doi.org/10.1080/13550280701620754
resource representing a document's title	Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1
has PubMed Central identifier	PMC7095411
has PubMed identifier	18097888
schema:publication	J Neurovirol
resource representing a document's body	covid:f7da12cb128e48642765cfa54c58920d5bce89c4#body_text
is schema:about of	named entity 'LATENCY' named entity 'GENE OF BOVINE HERPESVIRUS 1' named entity 'PROTEIN ' named entity 'THESE' named entity 'CYTOPLASM' named entity 'SUGGEST' named entity 'PROTEIN ' named entity '578' named entity 'BHV-1' named entity 'ORF' named entity 'CONTAIN' named entity 'NEUROVIROLOGY' named entity 'MAY BE' named entity 'CONTAINING' named entity 'STAINED' named entity 'JOURNAL ' named entity 'TRIGEMINAL GANGLIA' named entity 'CYCLE' named entity 'IMPORTANT' named entity 'IDENTIFICATION' named entity 'NOVEL PROTEIN' named entity 'RELATED' named entity 'FUSION PROTEIN' named entity 'LATENCY' named entity 'NEURONS' named entity 'REACTIVATION' named entity 'RF-C' named entity 'ANTISERUM' named entity 'INFECTED' named entity 'EXPRESSION' named entity 'CALVES' named entity 'ENCODED' named entity 'STUDIES' named entity 'neurons' named entity 'ORF' named entity 'Trigeminal ganglia' named entity 'ORF' named entity 'ORF' named entity 'apoptosis' named entity 'PBS' named entity 'protein' named entity 'peptide' named entity 'U.S.' named entity 'ORF' named entity 'fusion proteins' named entity 'antiserum' named entity 'protein' named entity 'antiserum' named entity 'BHV-1' named entity 'red cells' named entity 'Mission, KS' named entity 'RNA' named entity 'antiserum' named entity 'baculovirus' named entity 'stop codons' named entity 'BHV-1' named entity 'amino acids' named entity 'ORF' named entity 'protein' named entity 'expression vector' named entity 'bovine' named entity 'PBS' named entity 'SF9' named entity 'plaque forming units' named entity 'ORF' named entity 'BHV-1' named entity 'ORF' named entity 'lysed' named entity 'ORF' named entity 'ORF' named entity 'cross contamination' named entity 'spliced variant' named entity 'antiserum' named entity 'polyA' named entity 'staining' named entity 'ORF'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software