About: Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases

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About: Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases
Creator	Rink, Lothar Haase, Hajo Overbeck, Silke
Source	Medline; PMC
abstract	Zinc is required for multiple cellular tasks, and especially the immune system depends on a sufficient availability of this essential trace element. During the last decades, many studies attempted to affect the outcome of various diseases by zinc supplementation. These efforts either aimed at supporting immunity by zinc administration or at correcting a loss of zinc secondary to the disease to restore the zinc-dependent functions of the immune system. This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. In contrast, the results for the common cold and malaria are still not conclusive, and zinc was ineffective in most vaccination and rheumatoid arthritis studies. For AIDS and type 1 diabetes, zinc supplementation may even be a risk factor for increased mortality or deterioration of the glucose metabolism, respectively. In these cases, zinc supplementation should be used with care and limited to clearly zinc-deficient individuals.
has issue date	2008-02-05(xsd:dateTime)
bibo:doi	10.1007/s00005-008-0003-8
bibo:pmid	18250973
has license	no-cc
sha1sum (hex)	f85d33b30f4c9821c4c9d16f0712c4a2c25204ff
schema:url	https://doi.org/10.1007/s00005-008-0003-8
resource representing a document's title	Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases
has PubMed Central identifier	PMC7079749
has PubMed identifier	18250973
schema:publication	Arch Immunol Ther Exp (Warsz)
resource representing a document's body	covid:f85d33b30f4c9821c4c9d16f0712c4a2c25204ff#body_text
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