About: A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

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About: A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes
Creator	Katayama, Yukie Kuroda, Moegi Masuda, Tsuneyuki Mizutani, Tetsuya Nagai, Makoto Naoi, Yuki Oba, Mami Omatsu, Tsutomu Sakaguchi, Shoichi Tsuchiaka, Shinobu Yamazato, Hiroshi
Source	BioRxiv; MedRxiv
abstract	Enterovirus G (EV-G) belongs to the family of Picornaviridae. Two types of recombinant porcine EV-Gs carrying papain-like cysteine protease (PLCP) gene of porcine torovirus, a virus in Coronaviridae, are reported. Type 1 recombinant EV-Gs are detected in pig feces in Japan, USA, and Belgium and carry the PLPC gene at the junction site of 2C/3A genes, while PLPC gene replaces the viral structural genes in type 2 recombinant EV-G detected in pig feces in a Chinese farm. We identified a novel type 2 recombinant EV-G carrying the PLCP gene with flanking sequences in place of the viral structural genes in pig feces in Japan. The ~0.3 kb-long upstream flanking sequence had no sequence homology with any proteins deposited in GenBank, while the downstream ~0.9 kb-long flanking sequence included a domain having high amino acid sequence homology with a baculoviral inhibitor of apoptosis repeat superfamily. The pig feces, where the novel type 2 recombinant EV-G was detected, also carried type 1 recombinant EV-G. Although the phylogenetic analysis suggested that these two recombinant EV-Gs have independently evolved, type 1 recombinant EV-G might have served as a helper virus by providing viral structural proteins for dissemination of the type 2 recombinant EV-G.
has issue date	2019-01-02(xsd:dateTime)
bibo:doi	10.1101/510131
has license	medrxiv
sha1sum (hex)	f89618a7949b8ff9b92c87ca5b839a3107957b5c
schema:url	https://doi.org/10.1101/510131
resource representing a document's title	A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes
schema:publication	bioRxiv
resource representing a document's body	covid:f89618a7949b8ff9b92c87ca5b839a3107957b5c#body_text
is schema:about of	named entity 'types' named entity 'pig' named entity 'recombinant' named entity 'USA' named entity 'gene' named entity 'structural genes' named entity 'Picornaviridae' named entity 'Ryo' named entity 'VIRAL' named entity 'GENE' named entity 'HOMOLOGY' named entity 'PROTEINS' named entity 'CARRYING' named entity 'VIRAL' named entity 'GENE' named entity 'PAPAIN-LIKE CYSTEINE PROTEASE' named entity 'NO SEQUENCE' covid:arg/f89618a7949b8ff9b92c87ca5b839a3107957b5c named entity 'ENTEROVIRUS G' named entity 'ENTEROVIRUS G' named entity 'TYPE 1' named entity 'SUPERFAMILY' named entity 'NOVEL' named entity 'FAMILY' named entity 'USA' named entity 'PLACE' named entity 'WHERE' named entity 'IDENTIFIED' named entity 'G VIRUS' named entity '5 6' named entity 'CYSTEINE PROTEASE GENE' named entity 'INHIBITOR' named entity 'UPSTREAM' named entity 'PORCINE' named entity 'BELGIUM' named entity 'CARRY' named entity 'STRUCTURAL PROTEIN' named entity 'APOPTOSIS' named entity 'NOVEL' named entity 'DEFECTIVE' named entity 'IMAI' named entity '4 5' named entity 'PROTEIN ' named entity 'DOWNSTREAM' named entity 'PHYLOGENETIC ANALYSIS' named entity 'THESE' named entity 'FLANKING' named entity 'AMINO ACID SEQUENCE' named entity 'PORCINE TOROVIRUS' named entity 'DEPOSITED' named entity 'LONG' named entity 'REPEAT' named entity 'GENES' named entity 'DISSEMINATION' named entity 'PLPC' named entity 'RECOMBINANT' named entity 'CORONAVIRIDAE' named entity 'FARM' named entity 'DETECTED' named entity 'SEQUENCES' named entity 'FECES' named entity 'PICORNAVIRIDAE' named entity 'DOMAIN' named entity 'VIRAL STRUCTURAL PROTEINS' named entity '0.3' named entity 'PIG' named entity 'EVOLVED' named entity 'VIRUS' named entity 'STRUCTURAL GENES' named entity 'HAVE' named entity 'REPLACES' named entity 'HELPER VIRUS' named entity 'JAPAN' named entity 'HIGH'

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