About: Coronavirus membrane fusion mechanism offers a potential target for antiviral development

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus membrane fusion mechanism offers a potential target for antiviral development
Creator	Daniel, Susan Tang, Tiffany Jaimes, Javier Whittaker, Gary Bidon, Miya
Source	Elsevier; Medline; PMC
abstract	The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2020.104792
bibo:pmid	32272173
has license	no-cc
sha1sum (hex)	f964791f4f4f0b939150b1a2490208f72d029947
schema:url	https://doi.org/10.1016/j.antiviral.2020.104792
resource representing a document's title	Coronavirus membrane fusion mechanism offers a potential target for antiviral development
has PubMed Central identifier	PMC7194977
has PubMed identifier	32272173
schema:publication	Antiviral Res
resource representing a document's body	covid:f964791f4f4f0b939150b1a2490208f72d029947#body_text
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