About: Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Regulates the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 and the Activity of Intestinal Alkaline Phosphatase in Cultures

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About: Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Regulates the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 and the Activity of Intestinal Alkaline Phosphatase in Cultures Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Regulates the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 and the Activity of Intestinal Alkaline Phosphatase in Cultures
Creator	Choi, Rcy Dong, Ttx Du, Cyq Lau, Dtw Tsim, Kwk
Source	Medline; PMC
abstract	Yu Ping Feng San (YPFS), a Chinese herbal decoction comprising Astragali Radix (AR; Huangqi), Atractylodis Macrocephalae Rhizoma (AMR; Baizhu), and Saposhnikoviae Radix (SR; Fangfeng), has been used clinically to treat inflammatory bowel diseases (IBD). Previously, we demonstrated a dual role of YPFS in regulating cytokine release in cultured macrophages. In this study, we elucidated the anti-inflammatory effect of YPFS that is mediated through modulating the expression of three key enzymes involved in IBD: inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and intestinal alkaline phosphatase (IALP). In a lipopolysaccharide (LPS)-induced chronic-inflammation model of cultured murine macrophages, YPFS treatment suppressed the activation of iNOS and COX-2 expression in a dose-dependent manner. Conversely, application of YPFS in cultured small intestinal enterocytes markedly induced the expression of IALP in a time-dependent manner, which might strengthen the intestinal detoxification system. A duality of YPFS in modulating the expression of iNOS and COX-2 was determined here. The expression of iNOS and COX-2 in macrophages was induced by YPFS, and this activation was partially blocked by the NF-κB-specific inhibitor BAY 11-7082, indicating a role of NF-κB signaling. These YPFS-induced changes in gene regulation strongly suggest that the anti-inflammatory effects of YPFS are mediated through the regulation of inflammatory enzymes.
has issue date	2014-06-26(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0100382
bibo:pmid	24967898
has license	cc-by
sha1sum (hex)	fc5cc0fedf50af659b515f25de57a6c7d841d342
schema:url	https://doi.org/10.1371/journal.pone.0100382
resource representing a document's title	Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Regulates the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 and the Activity of Intestinal Alkaline Phosphatase in Cultures
has PubMed Central identifier	PMC4072625
has PubMed identifier	24967898
schema:publication	PLoS One
resource representing a document's body	covid:fc5cc0fedf50af659b515f25de57a6c7d841d342#body_text
is schema:about of	named entity 'INDUCIBLE NITRIC OXIDE SYNTHASE' named entity 'cyclooxygenase-2' named entity 'inhibitor' named entity 'anti-inflammatory' named entity 'Chinese' named entity 'Expression' named entity 'YU PING FENG SAN' named entity 'CULTURES' named entity 'CHINESE' covid:arg/fc5cc0fedf50af659b515f25de57a6c7d841d342 named entity 'ANCIENT' named entity 'THESE' named entity 'REGULATING' named entity 'INDUCIBLE NITRIC OXIDE SYNTHASE' named entity 'CYTOKINE RELEASE' named entity 'SAPOSHNIKOVIAE RADIX' named entity 'ANTI-INFLAMMATORY' named entity 'BLOCKED' named entity 'BAY' named entity 'HERBAL' named entity 'TREATMENT' named entity 'SYSTEM' named entity 'ANTI-INFLAMMATORY EFFECT' named entity 'DEMONSTRATED' named entity 'ENZYMES' named entity 'DOSE-DEPENDENT' named entity 'INDUCED' named entity 'INOS' named entity 'MEDIATED' named entity 'COX-2' named entity 'MARKEDLY' named entity 'EXPRESSION' named entity 'INFLAMMATORY' named entity 'TREAT' named entity 'HERE' named entity 'PREVIOUSLY' named entity 'INFLAMMATORY BOWEL DISEASES' named entity 'INTESTINAL ALKALINE PHOSPHATASE' named entity 'EXPRESSION OF INOS' named entity 'SPECIFIC' named entity 'CHINESE' named entity 'YU PING FENG SAN' named entity 'STUDY' named entity 'RHIZOMA' named entity 'CYCLOOXYGENASE-2' named entity 'USED' named entity 'HUANGQI' named entity 'MACROPHAGES' named entity 'INTESTINAL' named entity 'HERBAL' named entity 'CHRONIC' named entity 'INFLAMMATION' named entity 'ACTIVATION' named entity 'CYCLOOXYGENASE-2' named entity 'DECOCTION' named entity 'INTESTINAL ALKALINE PHOSPHATASE' named entity 'ACTIVITY' named entity 'EXPRESSION' named entity 'ALKALINE PHOSPHATASE ' named entity 'APPLICATION' named entity 'ASTRAGALI' named entity 'REGULATION' named entity 'CHANGES' named entity 'DUAL' named entity 'ROLE' named entity 'SUPPRESSED' named entity 'PARTIALLY' named entity 'TIME' named entity 'ENTEROCYTES' named entity 'IBD' named entity 'SIGNALING' named entity 'KEY' named entity 'INVOLVED' named entity 'DETERMINED' named entity 'INDICATING' named entity 'LIPOPOLYSACCHARIDE' named entity 'GENE REGULATION'

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