About: Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis

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About: Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
Creator	Da, Gabriella Thaís, & Cristina, Simone Diedrich, Denise Fernandes De Andrade, Saulo Flávio De Oliveira, Luís Fuentefria, Alexandre Gnoatto, Baggio Jean, Mickael Machado, Rosa Ruaro, Carine Teixeira, Mário Van De Weghe, Pierre Zimmer, Aline
source	Medline; PMC
abstract	Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml(−1))). However, compounds 2 (GM = 50 μg ml(−1)) and 3 (GM = 47.19 μg ml(−1)) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00348-4) contains supplementary material, which is available to authorized users.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1007/s42770-020-00348-4
bibo:pmid	32737869
has license	no-cc
sha1sum (hex)	fd98d8b4c4b717dbc12cbe10cc573694db22b433
schema:url	https://doi.org/10.1007/s42770-020-00348-4
resource representing a document's title	Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
has PubMed Central identifier	PMC7394049
has PubMed identifier	32737869
schema:publication	Braz J Microbiol
resource representing a document's body	covid:fd98d8b4c4b717dbc12cbe10cc573694db22b433#body_text
is schema:about of	named entity 'toxicity' named entity 'EFFICACY' named entity 'FUNGAL INFECTIONS' named entity 'STUDY' named entity 'BCG' named entity 'STRONG' named entity 'Candida' named entity 'profile' named entity 'safety' named entity 'compounds' named entity 'dermatophyte' named entity 'compounds' named entity 'problem' named entity 'global public health' named entity 'quinolines' named entity 'cytotoxic action' named entity 'global public health' named entity 'dermal' named entity 'dermatophyte' named entity 'toxicity' named entity 'dermatophytic' named entity 'antifungal' named entity 'dermatophytic' named entity 'dermatophytosis' named entity 'toxicological profile' named entity 'Quinolines' named entity 'antifungal' named entity 'compound' named entity 'hemocoel' named entity 'pig' named entity 'minimum inhibitory concentration' named entity 'quinoline' named entity 'DNA damage' named entity 'NMR' named entity 'toxicity' named entity 'antifungal agents' named entity 'Dremel' named entity '200 mesh' named entity 'negative control' named entity 'quinoline' named entity 'dermatophytes' named entity 'skin cells' named entity 'antibacterial' named entity 'HIV epidemic' named entity 'bleomycin' named entity 'chromatography' named entity 'genotoxicity' named entity 'toxic effects' named entity 'hydroxychloroquine' named entity 'invasive candidiasis' named entity 'venous blood' named entity 'filamentous fungi' named entity 'antifungal' named entity 'LogP' named entity 'cutaneous candidiasis' named entity 'Coleoptera' named entity 'C-4' named entity 'antifungal' named entity 'chorioallantoic membrane' named entity '37°C' named entity 'griseofulvin' named entity 'quinoline' named entity 'bone marrow' named entity 'deuterated solvent' named entity 'Invertebrate' named entity 'cytotoxicity assay' named entity 'chloroquine' named entity 'immunosuppressive'

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