About: Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus

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About: Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus
Creator	Scott, F Baldwin"', C Barlough, J Stoddart, C
Source	Elsevier; Medline; PMC
abstract	Specific pathogen free kittens were vaccinated with an unattenuated field isolate of canine coronavirus (ccv) either by aerosol or subcutaneously, and received boosting vaccinations four weeks later. Aerosolisation elicited a homologous virus-neutralising (vn) antibody response that increased steadily over a four-week period and levelled off one to two weeks after revaccination. The initial aerosolised dose produced an asymptomatic infection with excretion of ccv from the oropharynx up to eight days after vaccination; virus shedding was not detected, however, after the second inoculation. Cats vaccinated subcutaneously developed low vn antibody titres after the first ccv dose and experienced a strong anamnestic response after the second dose. Neutralising antibody titres then levelled off one to two weeks after revaccination at mean values somewhat lower than in cats vaccinated by aerosol. ccv was not isolated from the oropharynx after either subcutaneous dose. Four weeks after ccv boosting inoculations, vaccinated cats and sham-vaccinated control cats were divided into three subgroups and challenged by aerosol with the virulent ucd1 strain of feline infectious peritonitis virus (fipv ucd1) at three different dosage levels. Five of six cats (including sham-vaccinated controls) given the lowest challenge dose showed no signs of disease, while all other cats developed lesions typical of feline infectious peritonitis (fip). The five surviving cats developed fip after subsequent challenge with a fivefold higher dose of fipv. Thus heterotypic vaccination of cats with ccv did not provide effective protection against fipv challenge.
has issue date	1988-11-30(xsd:dateTime)
bibo:doi	10.1016/s0034-5288(18)30970-6
bibo:pmid	2850601
has license	els-covid
sha1sum (hex)	fd993078c0b3ffca161716125696ca01b106e173
schema:url	https://doi.org/10.1016/s0034-5288%2818%2930970-6
resource representing a document's title	Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus
has PubMed Central identifier	PMC7131371
has PubMed identifier	2850601
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:fd993078c0b3ffca161716125696ca01b106e173#body_text
is schema:about of	named entity 'peritonitis' named entity 'PERITONITIS' named entity 'USING' named entity 'CANINE CORONAVIRUS' named entity 'IMMUNISATION' named entity 'ATTEMPTED' named entity 'CATS' named entity 'FELINE' named entity 'peritonitis' named entity 'peplomer' named entity 'safe and effective' named entity 'homogenate' named entity 'antibodies' named entity 'pleuritis' named entity 'vaccination' named entity 'FIPV' named entity 'coronavirus' named entity 'antibody response' named entity 'anaesthesia' named entity 'antigen' named entity 'Barlough' named entity 'liver' named entity 'FIPV' named entity 'specific pathogen free' named entity 'vaccination' named entity 'oropharynx' named entity 'antibodies' named entity 'Barlough' named entity 'peplomer' named entity 'FIPV' named entity 'supernatant' named entity 'causative agent' named entity 'virus' named entity 'Barlough' named entity 'FIPV' named entity 'antibodies' named entity 'supernatants' named entity 'excretion' named entity 'Barlough' named entity 'immune responses' named entity 'survival time' named entity 'coronavirus' named entity 'cross reactivity' named entity 'coronavirus' named entity 'antigen' named entity 'vaccinating' named entity 'inoculation' named entity 'supernatants' named entity 'immunosorbent assay' named entity 'FIPV' named entity 'FIPV' named entity 'Stillwater, Oklahoma' named entity 'feline infectious peritonitis virus' named entity 'clinical signs' named entity 'mucosal immunity' named entity 'subcutaneous' named entity 'nebulised' named entity 'vaccination' named entity 'culture medium' named entity 'subcutaneously' named entity 'virus' named entity 'FIP' named entity 'anamnestic response' named entity 'FIPV' named entity 'L-15' named entity 'sensitised' named entity 'faeces' named entity 'aerosol' named entity 'peritonitis' named entity 'inactivated vaccine' named entity 'excretion' named entity 'vaccination' named entity 'FIPV' named entity 'FIPV' named entity 'FELINE infectious peritonitis virus' named entity 'immunogen' named entity 'virus' named entity 'antibody'

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