About: Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome

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About: Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
Creator	Liu, Daoyan Ni, Yinxing Tepel, Martin Yan, Zhengchen Zhao, Zhigang Zhong, Jian Zhu, Shanjun Zhu, Zhiming China, Chongqing, P
Source	Elsevier; Medline; PMC
abstract	To establish whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry the GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (P = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; P = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome.
has issue date	2006-02-28(xsd:dateTime)
bibo:doi	10.1016/j.lab.2005.10.001
bibo:pmid	16459167
has license	els-covid
sha1sum (hex)	fdd1b1b6446f2879815ebe9baa424054aa2e8f61
schema:url	https://doi.org/10.1016/j.lab.2005.10.001
resource representing a document's title	Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
has PubMed Central identifier	PMC7127450
has PubMed identifier	16459167
schema:publication	Journal of Laboratory and Clinical Medicine
resource representing a document's body	covid:fdd1b1b6446f2879815ebe9baa424054aa2e8f61#body_text
is schema:about of	named entity 'GENE A' named entity 'ASSOCIATION' named entity 'FEMALE GENDER' named entity 'TYPE 1' named entity 'PATIENTS' named entity 'ASSOCIATED WITH' named entity 'GENE A' named entity 'CARRY' named entity 'CLEAVAGE' named entity 'ANOVA' named entity 'STANDARD DEVIATION' named entity '1.36' named entity 'SINGLE NUCLEOTIDE POLYMORPHISM' named entity 'INDEX' named entity 'ACE2' named entity 'patients' named entity 'mass' named entity 'angiotensin-converting enzyme 2' named entity 'PCR' named entity '95% CI' named entity 'Abbreviations' named entity 'POLYMORPHISM' named entity 'INCREASED DIASTOLIC BLOOD PRESSURE' named entity 'SUBJECTS' named entity 'RESTRICTION ENDONUCLEASE' named entity 'ESTABLISH' named entity '0.005' named entity 'ELEVATED BLOOD PRESSURE' named entity 'GENOTYPE' named entity 'X CHROMOSOME' named entity 'ALLELES' named entity 'ABBREVIATIONS' named entity 'MULTIVARIATE LOGISTIC REGRESSION' named entity 'CONFIDENCE' named entity 'ALU' named entity '28P' named entity 'ACE1' named entity 'MED' named entity 'CHINESE' named entity 'PATIENTS' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'MALE' named entity 'FEMALE PATIENTS' named entity 'HIGHER' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'DIASTOLIC BLOOD PRESSURE' named entity 'BODY MASS INDEX' named entity 'CHINESE' named entity 'STUDY' named entity 'FEMALE' named entity 'WORLD HEALTH ORGANIZATION' named entity 'DETECTED' named entity 'POLYMORPHISM' named entity 'TYPE 2' named entity 'FREQUENCIES' named entity 'POLYMERASE CHAIN REACTION' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'ACE2' named entity 'METABOLIC SYNDROME' named entity 'ODDS RATIO' named entity 'ANALYSIS OF VARIANCE' named entity 'ALLELE' named entity 'LAB' named entity 'PCR' named entity 'HYPERTENSION' named entity 'BMI' named entity '80%' named entity 'CARRYING' named entity 'RATIO' named entity 'METABOLIC SYNDROME' named entity 'GENOTYPES' named entity 'USING'

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