About: A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

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About: A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques
Creator	Baric, Ralph Donaldson, Eric Huynh, Jeremy Legasse, Alfred Manoharan, Minsha Planer, Shannon Rawlings, Stephanie Brinton, Margo Vatter, Heather Wong, Scott Axthelm, Michael Colgin, Lois Dickerson, Mary Lewis, Anne Pecotte, Jerilyn
Source	Elsevier; Medline; PMC
abstract	Abstract Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were SHFV positive and the infections persisted for more than 10 years with detectable virus in the blood (100–1000 genomes/ml). The sequences of two baboon SHFV isolates that were amplified by a single passage in primary macaque macrophages had a high degree of identity to each other as well as to the genome of SHFV-LVR, a laboratory strain isolated in the 1960s. Infection of Japanese macaques with 100PFU of a baboon isolate consistently produced high level viremia, pro-inflammatory cytokines, elevated tissue factor levels and clinical signs indicating coagulation defects. The baboon virus isolate provides a reliable BSL2 model of viral hemorrhagic fever disease in macaques.
has issue date	2015-01-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.10.018
bibo:pmid	25463617
has license	els-covid
sha1sum (hex)	fee29e2cc9f2767225d2a59147b447494b57a9a7
schema:url	https://doi.org/10.1016/j.virol.2014.10.018
resource representing a document's title	A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques
has PubMed Central identifier	PMC4304765
has PubMed identifier	25463617
schema:publication	Virology
resource representing a document's body	covid:fee29e2cc9f2767225d2a59147b447494b57a9a7#body_text
is schema:about of	named entity 'Japanese macaques' named entity 'produced' named entity 'isolated' named entity 'macaques' named entity 'levels' named entity 'Infection' named entity 'infections' named entity 'Brinton' named entity 'M.A.' covid:arg/fee29e2cc9f2767225d2a59147b447494b57a9a7 named entity 'isolate' named entity 'persistent' named entity 'macrophages' named entity 'primary' named entity 'virus' named entity 'persisted' named entity 'clinical signs' named entity 'baboon' named entity 'laboratory' named entity 'infected' named entity 'SHFV' named entity 'macaque' named entity 'laboratory strain' named entity 'macaques' named entity 'Virology' named entity 'SHFV' named entity 'Simian hemorrhagic fever' named entity 'genome' named entity 'CD163' named entity 'multiple sequence alignment' named entity 'Applied Biosystems' named entity 'electrophoresed' named entity 'SHFV' named entity 'genome' named entity 'sclera' named entity 'SHFV' named entity 'dry ice' named entity 'closely resemble' named entity 'SHFV' named entity 'SHFV' named entity 'qRT-PCR' named entity 'SHFV' named entity 'Alexa Fluor' named entity 'SHFV' named entity 'SHFV' named entity 'myocardium' named entity 'nucleocapsid' named entity 'loading control' named entity 'barcode' named entity 'PCR' named entity 'Olive baboons' named entity 'digital camera' named entity 'RNA' named entity 'Applied Biosystems' named entity 'macrophage' named entity 'mice' named entity 'hemorrhage' named entity 'bacterial sepsis' named entity 'dextrose' named entity 'baboon' named entity 'macaque' named entity 'nucleocapsid' named entity 'SHFV' named entity 'macaques' named entity 'primate' named entity 'London' named entity 'prophylactically'

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