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In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. Along with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity.

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  • Endothelial dysfunction
  • Disfunzione endoteliale
  • خلل بطاني
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  • في الأمراض الوعائية، فإن الخلل الوظيفي للطبقة البطانية أو الخلل البطاني (بالإنجليزية: Endothelial dysfunction)‏ هي حالة مرضية جهازية تصيب البطانة الغشائية للأوعية الدموية. كما يمكن تعريفها أيضا هو عدم التوازن بين المواد المضيقة والمواد الموسعة للأوعية الدموية التي تؤثر على البطانة الغشائية أو تنتج منها. الوظيفة الطبيعية للخلايا البطانية هي التأثير في تجلط الدم والتصاق الصفيحات الدموية ووظائف مناعية والتحكم في حجم حيز السوائل (العصارة الخلوية والسائل خارج الخلوي) ومحتواه من الإلكتروليتات.
  • Per disfunzione endoteliale si intende un'alterazione della normale funzione endoteliale, che comporta la perdita di alcune caratteristiche strutturali e/o funzionali. Per "attivazione endoteliale" si intende invece l'acquisizione da parte dell'endotelio di nuove proprietà, come l'espressione delle molecole adesive durante l'infiammazione. I fattori, che possono causare un danno funzionale dell'endotelio, sono numerosi e per la maggior parte si identificano con i fattori di rischio cardiovascolare.
  • In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium. Along with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity.
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