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Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Piperaquine was developed under the Chinese National Malaria Elimination Programme in the 1960s and was adopted throughout China as a replacement for the structurally similar antimalarial drug chloroquine. Due to widespread parasite resistance to piperaquine, the drug fell out of use as a monotherapy, and is instead used as a partner drug for artemisinin combination therapy. Piperaquine kills parasites by disrupting the detoxification of host heme.

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  • Piperaquine
  • Piperachina
  • Piperakuin
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  • Piperachina (łac. piperaquinum) – wielofunkcyjny organiczny związek chemiczny, pochodna chinoliny, stosowany w leczeniu malarii w połączeniu z dihydroartemizyną.
  • Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Piperaquine was developed under the Chinese National Malaria Elimination Programme in the 1960s and was adopted throughout China as a replacement for the structurally similar antimalarial drug chloroquine. Due to widespread parasite resistance to piperaquine, the drug fell out of use as a monotherapy, and is instead used as a partner drug for artemisinin combination therapy. Piperaquine kills parasites by disrupting the detoxification of host heme.
  • Piperakuin adalah obat antiparasit yang digunakan bersama untuk menangani malaria. Piperakuin dikembangkan dalam Program Eliminasi Malaria Nasional Tiongkok pada era 1960-an dan diangkat di seluruh Tiongkok sebagai pengganti klorokuin, obat antimalaria yang memiliki struktur serupa. Karena resistensi parasit terhadap piperakuin yang tersebar luas, piperakuin tidak digunakan sebagai terapi tunggal. Piperakuin digunakan dalam dalam terapi kombinasi artemisinin. Piperakuin membunuh parasit dengan mengganggu detoksifikasi heme inang.
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