About: Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
Creator	Wu, A Lee, N Chan, M Hui, D Sung, J Chan, I Wong, C Chung, S Lam, C Ip, W Lam, W Lit, L
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. We investigated changes in plasma T helper (Th) cell cytokines, inflammatory cytokines and chemokines in 20 patients diagnosed with SARS. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine interferon (IFN)-γ, inflammatory cytokines interleukin (IL)-1, IL-6 and IL-12 for at least 2 weeks after disease onset, but there was no significant elevation of inflammatory cytokine tumour necrosis factor (TNF)-α, anti-inflammatory cytokine IL-10, Th1 cytokine IL-2 and Th2 cytokine IL-4. The chemokine profile demonstrated significant elevation of neutrophil chemokine IL-8, monocyte chemoattractant protein-1 (MCP-1), and Th1 chemokine IFN-γ-inducible protein-10 (IP-10). Corticosteroid reduced significantly IL-8, MCP-1 and IP-10 concentrations from 5 to 8 days after treatment (all P < 0·001). Together, the elevation of Th1 cytokine IFN-γ, inflammatory cytokines IL-1, IL-6 and IL-12 and chemokines IL-8, MCP-1 and IP-10 confirmed the activation of Th1 cell-mediated immunity and hyperinnate inflammatory response in SARS through the accumulation of monocytes/macrophages and neutrophils.
has issue date	2004-04-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2249.2004.02415.x
bibo:pmid	15030519
has license	bronze-oa
sha1sum (hex)	00039b94e6cb7609ecbddee1755314bcfeb77faa
schema:url	https://doi.org/10.1111/j.1365-2249.2004.02415.x
resource representing a document's title	Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
has PubMed Central identifier	PMC1808997
has PubMed identifier	15030519
schema:publication	Clinical & Experimental Immunology
resource representing a document's body	covid:00039b94e6cb7609ecbddee1755314bcfeb77faa#body_text
is schema:about of	named entity 'cell-mediated immunity' named entity 'weeks' named entity 'macrophages' covid:arg/00039b94e6cb7609ecbddee1755314bcfeb77faa named entity 'accumulation' named entity 'cytokine' named entity 'patients' named entity 'caused' named entity 'investigated' named entity 'concentrations' named entity 'profile' named entity 'coronavirus' named entity 'emerged' named entity 'Th1' named entity 'cytokine' named entity 'cytokine' named entity 'IL-12' named entity 'SARS' named entity 'MCP-1' named entity 'IL-12' named entity 'IP-10' named entity 'Th1' named entity 'IL-2' named entity 'IL-8' named entity 'IFN' named entity 'inflammatory cytokines' named entity 'IP-10' named entity 'neutrophils' named entity 'plasma' named entity 'coronavirus' named entity 'cytokine' named entity 'inflammatory response' named entity 'IL-8' named entity 'chemokines' named entity 'cytokines' named entity 'plasma' named entity 'IL-12' named entity 'proinflammatory cytokines' named entity 'IL-12' named entity 'proinflammatory' named entity 'chemokine' named entity 'CXC chemokine' named entity 'IL-6' named entity 'fluorescence' named entity 'chemokines' named entity 'monoclonal antibody' named entity 'chemoattractant' named entity 'fluorescence' named entity 'protein' named entity 'Th1' named entity 'chemokines' named entity 'cytokine' named entity 'plasma' named entity 'normal range' named entity 'MCP-1' named entity 'chemokine' named entity 'proinflammatory cytokines' named entity 'SARS' named entity 'inflammatory cytokines' named entity 'Th1' named entity 'chemokines' named entity 'protein' named entity 'pathogenesis' named entity 'ARDS' named entity 'SARS' named entity 'PMN' named entity 'coronaviruses' named entity 'Prince of Wales' named entity 'IL-1' named entity 'acute lung injury'

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