About: Targeting drug delivery in the vascular system: Focus on endothelium()

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Targeting drug delivery in the vascular system: Focus on endothelium() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeting drug delivery in the vascular system: Focus on endothelium()
Creator	Edu, Brenner, Jacob Ferguson, Laura Glassman, Patrick Kiseleva, Raisa Muzykantov, Vladimir Myerson, Jacob Shuvaev, Vladimir Upenn, Muzykant@pennmedicine
Source	Elsevier; Medline; PMC
abstract	The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the site of administration to the intended site of action. In many cases, components of the vascular system represent therapeutic targets. Endothelial cells, which line the luminal surface of the vasculature, play a tripartite role of the key target, barrier, or victim of nanomedicines in the bloodstream. Circulating DDS may accumulate in the vascular areas of interest and in off-target areas via mechanisms bypassing specific molecular recognition, but using ligands of specific vascular determinant molecules enables a degree of precision, efficacy, and specificity of delivery unattainable by non-affinity DDS. Three decades of research efforts have focused on specific vascular targeting, which have yielded a multitude of DDS, many of which are currently undergoing a translational phase of development for biomedical applications, including interventions in the cardiovascular, pulmonary, and central nervous systems, regulation of endothelial functions, host defense, and permeation of vascular barriers. We discuss the design of endothelial-targeted nanocarriers, factors underlying their interactions with cells and tissues, and describe examples of their investigational use in models of acute vascular inflammation with an eye on translational challenges.
has issue date	2020-06-21(xsd:dateTime)
bibo:doi	10.1016/j.addr.2020.06.013
bibo:pmid	32579890
has license	no-cc
sha1sum (hex)	002c6a7e4b04193230529c0313c0368b2de6936a
schema:url	https://doi.org/10.1016/j.addr.2020.06.013
resource representing a document's title	Targeting drug delivery in the vascular system: Focus on endothelium()
has PubMed Central identifier	PMC7306214
has PubMed identifier	32579890
schema:publication	Adv Drug Deliv Rev
resource representing a document's body	covid:002c6a7e4b04193230529c0313c0368b2de6936a#body_text
is schema:about of	named entity 'represent' named entity 'intended' named entity 'vascular system' named entity 'endothelium' named entity 'drug delivery' named entity 'target' named entity 'site' named entity 'drug delivery systems' named entity 'DDS' named entity 'biomedical' named entity 'eye' named entity 'key' named entity 'barriers' named entity 'vascular' named entity 'transporting' named entity 'vascular' named entity 'investigational' named entity 'play' named entity 'targeting' named entity 'DDS' named entity 'DDS' named entity 'endothelial' named entity 'DDS' named entity 'nanocarriers' named entity 'mechanisms' named entity 'plasminogen' named entity 'lungs' named entity 'non-specific' named entity 'P-selectin' named entity 'sub-cellular' named entity 'invaginations' named entity 'lysosomes' named entity 'NF-κB' named entity 'vascular cells' named entity 'physiology' named entity 'endocytosis' named entity 'biodistribution' named entity 'bleach' named entity 'ischemia-reperfusion' named entity 'avidity' named entity 'WBC' named entity 'TfR' named entity 'intracellular localization' named entity 'animal models' named entity 'endothelium' named entity 'ligands' named entity 'reperfusion injury' named entity 'ligands' named entity 'vs. time' named entity 'small particles' named entity 'preclinical' named entity 'Redox-active' named entity 'antibodies' named entity 'positive and negative' named entity 'ICAM-1' named entity 'PECAM' named entity 'antibodies' named entity 'inflammation' named entity 'IL-1R' named entity 'ICAM-1' named entity 'diagnostic imaging' named entity 'caveolae' named entity 'proteases' named entity 'pulmonary embolism' named entity 'endosomes' named entity 'recombinant' named entity 'cell junction' named entity 'lumen' named entity 'mouse model' named entity 'nitric oxide' named entity 'organ' named entity 'MyD88' named entity 'epitopes'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software