About: Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients

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About: Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients
Creator	Park, Hyun Shin, Ho-Joon Kang, Homan Chong, Chom-Kyu Yeo, Seon-Ju Rah, Yoonhyuk Yu, Kyoungsik Choi, Hak Mai, Le Thanh, Le Vu, Hoang Bui, Thi Cuc, Duy Dao, Tung Le Khanh Hang, Nguyen Nguyen, Viet Phuong, Mai Thi, Anh Thi, Trinh Tien, Thuy
source	Medline; PMC
abstract	Accurate and rapid diagnosis of highly pathogenic avian influenza A H5N1 is of critical importance for the effective clinical management of patients. Here, we developed a rapid and simultaneous detection toolkit for influenza A H5 subtype viruses in human samples based on a bioconjugate of quantum dots (QDs) assembly and a smartphone-based rapid dual fluorescent diagnostic system (SRDFDS). Methods: Two types of QDs were assembled on a latex bead to enhance the detection sensitivity and specificity of influenza A infection (QD580) and H5 subtype (QD650). The dual signals of influenza A and H5 subtype of H5N1-infected patients were detected simultaneously and quantified separately by SRDFDS equipped with two emission filters. Results: Our results showed a high sensitivity of 92.86% (13/14) and 78.57% (11/14), and a specificity of 100% (38/38, P < 0.0001) and 97.37% (37/38) for influenza A and H5 subtype detection, respectively. Conclusion: Therefore, our multiplex QD bioconjugates and SRDFDS-based influenza virus detection toolkit potentially provide accurate and meaningful diagnosis information with improved detection accuracies and sensitivities for H5N1 patients.
has issue date	2018-11-29(xsd:dateTime)
bibo:doi	10.7150/thno.28027
bibo:pmid	30613288
has license	cc-by-nc
sha1sum (hex)	005c43980edf3fcc2a4d12ee7ad630ddb651ce6e
schema:url	https://doi.org/10.7150/thno.28027
resource representing a document's title	Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients
has PubMed Central identifier	PMC6299699
has PubMed identifier	30613288
schema:publication	Theranostics
resource representing a document's body	covid:005c43980edf3fcc2a4d12ee7ad630ddb651ce6e#body_text
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