About: Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study
Creator	Doleans-Jordheim, Anne Eymery, Mathilde Mainguy, Catherine Morfin, Florence Ohlmann, Camille Perceval, Marie Reix, Philippe
topic	covid:009892e02bc1a4c9abf6f547b979e68ecbde8087#this
Source	Medline; PMC
abstract	BACKGROUND: Viral respiratory tract infections are common during early childhood. How they impact cystic fibrosis lung disease history in young children is poorly known. The principal aim of our study was to determinate respiratory tract infections frequency in this cystic fibrosis young population. Secondary outcomes were nature of viral agents recovered and impact of such infections. METHODS: We conducted a prospective cohort study of 25 children affected by cystic fibrosis and aged less than 2 years. Nasal samplings were taken systematically monthly or bimonthly with additional samples taken during respiratory tract infections episodes. Ten pathogens were tested by a combination of five duplex RT-PCRs or PCRs: influenza A and B, respiratory syncytial virus (RSV), metapneumovirus (MPV), rhinovirus/enterovirus (RV/EV)), coronavirus (HKU1, NL63, 229E and OC43), parainfluenza virus (1–4), adenovirus and bocavirus (Respiratory Multi-Well System MWS r-gene®, BioMérieux, Marcy l’Étoile, France). Cycle thresholds (CTs) were reported for all positive samples and considered positive for values below 40. Quantitative variables were compared using a nonparametric statistical test (Wilcoxon signed rank for paired comparisons). Pearson’s correlation coefficient (r) was used to assess relationships between two variables. Statistical analyses were performed using SAS v9.4 (SAS Institute, Cary, NC, USA) or GraphPad Prism V6.00 (GraphPad Software, La Jolla, CA, USA). The significance level was set at 0.05. RESULTS: The mean age at inclusion was 9.6 ± 6.7 months. The patients had 3.4 ± 1.7 respiratory tract infections episodes per child per year. Forty-four respiratory tract infections (69%) were associated with virus: rhinovirus and enterovirus (RV/EV) were implied in 61% of them and respiratory syncytial virus (RSV) in 14%. Only one patient required hospitalization for lower respiratory tract infections. 86% of the patients were treated by antibiotics for a mean of 13.8 ± 6.2 days. RSV infections (n = 6) were usually of mild severity. CONCLUSIONS: Respiratory tract infections in young children with cystic fibrosis were of mild severity, rarely requiring hospitalization. Unsurprisingly, RV/EV were the most frequent agents. RSV-related morbidity seems low in this population. This raises the question of the usefulness of RSV preventive medication in this young population.
has issue date	2019-09-03(xsd:dateTime)
bibo:doi	10.1186/s12985-019-1208-7
bibo:pmid	31481063
has license	cc-by
sha1sum (hex)	009892e02bc1a4c9abf6f547b979e68ecbde8087
schema:url	https://doi.org/10.1186/s12985-019-1208-7
resource representing a document's title	Viral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study
has PubMed Central identifier	PMC6724274
has PubMed identifier	31481063
schema:publication	Virol J
resource representing a document's body	covid:009892e02bc1a4c9abf6f547b979e68ecbde8087#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/009892e02bc1a4c9abf6f547b979e68ecbde8087
is schema:about of	named entity 'respiratory tract infections' named entity 'The principal' named entity 'frequency' named entity 'Viral' named entity 'STUDY' named entity 'SECONDARY' covid:arg/009892e02bc1a4c9abf6f547b979e68ecbde8087 named entity 'FREQUENCY' named entity 'CYSTIC FIBROSIS LUNG' named entity 'YEAR' named entity 'VIRAL' named entity 'COMMON' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PRINCIPAL' named entity 'IMPACT' named entity 'LUNG DISEASE' named entity 'CYSTIC FIBROSIS' named entity 'CYSTIC FIBROSIS' named entity 'NATURE' named entity 'RECOVERED' named entity 'HOW' named entity 'VIRAL' named entity 'AIM' named entity 'DISEASE HISTORY' named entity 'DETERMINATE' named entity 'STUDY' named entity 'OUR' named entity 'YOUNG CHILDREN' named entity 'OUTCOMES' named entity 'POPULATION' named entity 'EARLY CHILDHOOD' named entity 'POORLY' named entity 'KNOWN' named entity 'BACKGROUND' named entity 'INFECTIONS' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'YOUNG CHILDREN' named entity 'SEASONAL' named entity 'PROSPECTIVE' named entity 'YOUNG' named entity 'significance level' named entity 'virus' named entity 'adenoviruses' named entity 'virus' named entity 'American Academy of Pediatrics' named entity 'virus' named entity 'Pearson correlation' named entity 'clinical symptoms' named entity 'GraphPad Prism' named entity 'influenza' named entity 'RSV' named entity '8 days' named entity 'picornavirus' named entity 'bacterial flora' named entity 'palivizumab' named entity 'Z-scores' named entity 'viruses' named entity 'pathological conditions' named entity 'pathogenicity' named entity 'RSV infection' named entity 'young children' named entity 'virally' named entity 'morbidity' named entity 'URTIs' named entity 'short-term' named entity 'virus' named entity 'Achromobacter xylosoxidans' named entity 'adenovirus' named entity 'Pearson correlation' named entity 'health status' named entity 'RSV infection' named entity 'environmental factors' named entity 'URTI'

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