About: Non-viral siRNA delivery to the lung

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-viral siRNA delivery to the lung
Creator	Chen, Jianzhu Lu, James Thomas, Mini Klibanov, Alexander
Source	Elsevier; Medline; PMC
abstract	Abstract SiRNAs exert their biological effect by guiding the degradation of their cognate mRNA sequence, thereby shutting down the corresponding protein production (gene silencing by RNA interference or RNAi). Due to this property, siRNAs are emerging as promising therapeutic agents for the treatment of inherited and acquired diseases, as well as research tools for the elucidation of gene function in both health and disease. Because of their lethality and prevalence, lung diseases have attracted particular attention as targets of siRNA-mediated cures. In addition, lung is accessible to therapeutic agents via multiple routes, e.g., through the nose and the mouth, thus obviating the need for targeting and making it an appealing target for RNAi-based therapeutic strategies. The clinical success of siRNA-mediated interventions critically depends upon the safety and efficacy of the delivery methods and agents. Delivery of siRNAs relevant to lung diseases has been attempted through multiple routes and using various carriers in animal models. This review focuses on the recent progress in non-viral delivery of siRNAs for the treatment of lung diseases, particularly infectious diseases. The rapid progress will put siRNA-based therapeutics on fast track to the clinic.
has issue date	2007-03-30(xsd:dateTime)
bibo:doi	10.1016/j.addr.2007.03.003
bibo:pmid	17459519
has license	els-covid
sha1sum (hex)	009e8db6e8ad5814895dfd7c3207e46d0bb5d326
schema:url	https://doi.org/10.1016/j.addr.2007.03.003
resource representing a document's title	Non-viral siRNA delivery to the lung
has PubMed Central identifier	PMC7103292
has PubMed identifier	17459519
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:009e8db6e8ad5814895dfd7c3207e46d0bb5d326#body_text
is schema:about of	named entity 'MOUTH' named entity 'RNAI' named entity 'INFECTIOUS DISEASES' named entity 'NON-' named entity 'LETHALITY' named entity 'THERAPEUTIC AGENTS' named entity 'DELIVERY METHODS' named entity 'LUNG' named entity 'DUE TO' named entity 'EFFICACY' named entity 'PROPERTY' named entity 'BIOLOGICAL EFFECT' named entity 'GENE FUNCTION' named entity 'ROUTES' named entity 'RAPID' named entity 'CURES' named entity 'NOSE' named entity 'focuses' named entity 'carriers' named entity 'tools' named entity 'therapeutic' named entity 'infectious diseases' named entity 'clinical' named entity 'mouth' named entity 'gene' named entity 'CLINICAL SUCCESS' named entity 'THERAPEUTICS' named entity 'VIRAL' named entity 'ANIMAL MODELS' named entity 'TARGETING' named entity 'TARGET' named entity 'TARGETS' named entity 'LUNG' named entity 'NON-' named entity 'VIRAL' named entity 'SIRNA DELIVERY' named entity 'ADDITION' named entity 'APPEALING' named entity 'LUNG DISEASES' named entity 'RESEARCH' named entity 'THERAPEUTIC' named entity 'PREVALENCE' named entity 'RNA INTERFERENCE' named entity 'MULTIPLE' named entity 'PROGRESS' named entity 'HAVE' named entity 'SILENCING' named entity 'SAFETY' named entity 'VARIOUS' named entity 'CARRIERS' named entity 'SIRNA' named entity 'SIRNAS' named entity 'MEDIATED' named entity 'CLINIC' named entity 'PARTICULAR' named entity 'NEED FOR' named entity 'BASED' named entity 'TREATMENT' named entity 'ACQUIRED DISEASES' named entity 'INTERVENTIONS' named entity 'STRATEGIES' named entity 'EXERT' named entity 'GUIDING' named entity 'HEALTH AND DISEASE' named entity 'TOOLS' named entity 'FAST' named entity 'ATTENTION' named entity 'USING' named entity 'TRACK' named entity 'THEIR' named entity 'RELEVANT' named entity 'REVIEW' named entity 'DEGRADATION' named entity 'SEQUENCE' named entity 'INHERITED' named entity 'ACCESSIBLE' named entity 'MRNA' named entity 'DELIVERY'

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